Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Plasma proteome |
Proteomic analyses will be performed by liquid nano-chromatography coupled to label-free tandem mass spectrometry (label-free nLC-MS/MS). This technique allows the relative quantification of the abundance of each protein in each sample, making it possible to assess those with differential expression in the different study groups. |
It will be carried out on blood samples from the study participants before starting the intervention and at the end. Estimated duration of 3 months |
|
Primary |
Lipid peroxidation |
Lipid peroxidation is determined by thiobarbituric acid reactive substances (TBARS) method. |
It will be carried out on blood samples from the study participants before starting the intervention and at the end. Estimated duration of 1 month |
|
Secondary |
Aldolase |
Aldolase is measured using an AU 5800 analyzer (Beckman Coulter). |
It will be carried out on blood samples from the study participants before starting the intervention and at the end. Estimated duration of 1 month |
|
Secondary |
C-reactive protein (CRP) |
C-reactive protein (CRP) ie measured using an AU 5800 analyzer (Beckman Coulter). |
It will be carried out on blood samples from the study participants before starting the intervention and at the end. Estimated duration of 1 month |
|
Secondary |
Impact of fibromyalgia |
FIQR (Revised Fibromyalgia Impact Questionnaire) will be used to evaluate the functional capacity in daily living activities |
It will be carried out on blood samples from the study participants before starting the intervention and at the end. Estimated duration of 20 minutes |
|
Secondary |
Quality of Life |
SF-12 (Quality of Life Questionnaire) is used to assess quality of life. |
It will be carried out on blood samples from the study participants before starting the intervention and at the end. Estimated duration of 20 minutes |
|
Secondary |
Red blood cells |
Red blood cells are measured using a DxH 900 Workcell Automated Hematology Solution (Beckman Coulter). |
It will be carried out on blood samples from the study participants before starting the intervention and at the end. Estimated duration of 1 month |
|
Secondary |
Haemoglobin |
Haemoglobin is measured using a DxH 900 Workcell Automated Hematology Solution (Beckman Coulter). |
It will be carried out on blood samples from the study participants before starting the intervention and at the end. Estimated duration of 1 month |
|
Secondary |
Fibrinogen |
Fibrinogen is measured using a DxH 900 Workcell Automated Hematology Solution (Beckman Coulter). |
It will be carried out on blood samples from the study participants before starting the intervention and at the end. Estimated duration of 1 month |
|
Secondary |
Total cholesterol |
Total cholesterol is measured by a spectrophotometric procedure using an Olympus AU 5400 analyzer (Beckman Coulter). |
It will be carried out on blood samples from the study participants before starting the intervention and at the end. Estimated duration of 1 month |
|
Secondary |
Cholesterol ratio |
Cholesterol ratio is measured by a spectrophotometric procedure using an Olympus AU 5400 analyzer (Beckman Coulter). |
It will be carried out on blood samples from the study participants before starting the intervention and at the end. Estimated duration of 1 month |
|
Secondary |
LDL cholesterol |
LDL cholesterol is measured by a spectrophotometric procedure using an Olympus AU 5400 analyzer (Beckman Coulter). |
It will be carried out on blood samples from the study participants before starting the intervention and at the end. Estimated duration of 1 month |
|
Secondary |
Cortisol |
Cortisol level is determined in serum samples by a fluorescence polarization immunoassay using an AxSYM (Abbott Laboratories, IL, USA). |
It will be carried out on blood samples from the study participants before starting the intervention and at the end. Estimated duration of 1 month |
|