The Effect of Sympathetic Dysfunction on Muscle Spindle in Fibromyalgia

Status Not yet recruiting

Clinical Trial Summary

This study aims to reveal whether there is an impairment in the sympathetic regulation of muscle spindle sensitivity in patients with fibromyalgia syndrome (FMS).

Clinical Trial Description

The common muscle pain and fatigue symptoms of FMS can be explained by impaired sympathetic regulation of muscle spindle sensitivity. The aim of this study is to reveal whether there is an impairment in the sympathetic regulation of muscle spindle sensitivity in FMS patients. Material method: In the first stage, resting sympathetic tone measurement and resting H-reflex and T-reflex recordings will be taken in all cases. Sympathetic tone measurement will be performed and H-reflex and T-reflex recordings will be taken during and after sympathetic stimulation maneuvers (mental arithmetic calculation and cold application) in FMS patients and healthy control subjects. In the second phase, the first dose of pregabalin will be given to patients diagnosed with FMS and prescribed pregabalin. Pregabalin is known to reduce sympathetic activity in FMS. After oral administration of pregabalin, its peak plasma concentration is reached in 0.9-1.3 hours. Therefore, 1.5 hours later, sympathetic tone measurement will be made at rest and during the sympathetic stimulation maneuver, and H-reflex and T-reflex recordings will be taken. Patients in the healthy control group will not be given pregabalin. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05704374
Study type	Interventional
Source	Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Contact	TUGBA AYDIN, Assoc Prof
Phone	+905324622162
Email	drtugbaaydin@gmail.com
Status	Not yet recruiting
Phase	N/A
Start date	November 2, 2023
Completion date	December 1, 2023

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