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Role of Senescent Cells in Uterine Fibroid Pathogenesis (SOUL Study) — SOUL  

Leiomyoma Clinical Trial

Official title:
Role of Senescent Cells in Uterine Fibroid Pathogenesis

Clinical Trial Summary

The investigators are evaluating the role of senescent cells in uterine fibroids.

Clinical Trial Description

Uterine fibroids are prevalent tumors of uterus characterized by excessive fibrotic tissues. Using new cutting-edge computational methods, the investigators have found that small groups of senescent cells in fibroids work in concert with immune cells to produce soluble factors in fibroid tissues to create a feed-forward loop leading to fibrosis. This project seeks to unravel key cell-cell communication networks involving senescent and immune cells in fibroids to develop new treatments for uterine fibroids. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06135870
Study type Observational
Source Johns Hopkins University
Contact James Segars, MD
Phone 410-614-2000
Email jsegars2@jhmi.edu
Status Recruiting
Phase
Start date November 1, 2023
Completion date December 31, 2027
View Details
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