Premature Birth Clinical Trial
Official title:
Effect of Low Dose Aspirin on Birthweight in Twins: The GAP Trial
Low-dose aspirin started in the first-trimester has been associated with a decrease of preeclampsia, fetal growth restriction and preterm birth in high-risk pregnancies. Multiple pregnancies are considered a risk factor for all those adverse outcomes. The main objective of the current trial is to evaluate whether a dose of 80 mg of aspirin is associated with an improvement of birthweight compared to placebo in twin pregnancies.
Twin pregnancies represent approximately 3% of births and are associated with increased risks
of complications such as preeclampsia, fetal growth restriction and preterm birth. All of
these complications are commonly associated impaired placental function and low birth weight.
Most prophylactic measures tested over the years have failed to prevent these adverse
outcomes in twin pregnancies. Since administration of low-dose of aspirin can improve
placental function and all these adverse outcomes in high-risk pregnancies, mainly in women
with prior adverse outcomes, we suggest that similar benefits could be seen in twins. We are
expecting that the administration of low-dose of aspirin starting in the first-trimester in
twin pregnancies could lead to an improvement of placental function, a reduction or these
adverse perinatal outcomes and therefore to an improvement of birthweight.
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