Premature Birth Clinical Trial
Official title:
Evaluation of Dose-response Effect of Acetylsalicylic Acid on Placental Development, Preterm Birth, Fetal Growth and Hypertension in Pregnancy in Women With Previous History of Preeclampsia
Placental insufficiency is the source of preeclampsia (PE) and intrauterine growth
retardation (IUGR). Current data demonstrate a significant beneficial effect of prophylactic
use of aspirin on the recurrence of placental insufficiency and its complications, mainly
preeclampsia, when started early in pregnancy. However, there is a significant heterogeneity
in medical practice in Canada and around the world in terms of the dose of aspirin used.
The objectives of this study are: 1) Evaluate whether a dose of 160 mg of aspirin is
associated with greater improvement in placental function assessed by biochemistry (sFlt-1
and endoglin) and ultrasound (uterine artery Doppler) than a dose of 80 mg in women with a
history of PE, 2) Assess whether the change is dependent on platelet aggregation measured by
a test used in several Canadian centers (PFA-100).
Many studies suggest that aspirin (acetylsalicylic acid) at low dose significantly reduces
the incidence of preeclampsia. More recent data have shown that, when administered before 16
weeks of pregnancy, aspirin can prevent over 50% of preeclampsia, severe preeclampsia, and
IUGR but also a significant proportion of the rate of preterm births. Current data also
demonstrate a beneficial effect of prophylactic use of aspirin when started early in
pregnancy in populations composed of high-risk patients with a history of preeclampsia and /
or other pregnancy complications related to poor placental function.
Beside, many clinicians are already using aspirin in the context of a proven benefit.
However, the usual dose prescribed in Canada today is 80 mg while the most favorable studies
have used a slightly higher dose of aspirin (100 mg).
Moreover, it has been demonstrated that the time of day during which aspirin was administered
was also a very important factor regarding the effect on blood pressure and adverse outcomes
of the majority of pregnancy. Yet the majority of studies in this context have not specified
the time of day at which aspirin was or had been taken, possibly underestimating the effect
thereof.
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