Pre-Eclampsia Clinical Trial
Official title:
Screening for Placental Insufficiency by a Combination of Second Trimester Uterine Artery Doppler and Maternal Serum Leptin and Lipids
To assess the role of uterine artery and maternal serum leptin and lipids and their combination in screening for pre-eclampsia and small-for-gestational-age (SGA) fetuses at 20-24 weeks of gestation
Pre-eclampsia (PE) and intrauterine growth restriction (IUGR) are known as major factors in
perinatal morbidity and mortality. Routine antenatal care is focused on the detection of
women at increased risk to apply this population a program of careful monitoring and
appropriate intervention.
Uterine artery Doppler during anomaly scan at 20 to 24 weeks in selected women at increased
risk, has proved to be accurate to detect those who will develop PE or IUGR during the
second half of pregnancy. Studies have reported detection rate of 50-70% for a 5% false
positive rate in women developing early pre-eclampsia.
A variety of proteins and hormones have been studied as potential markers for pre-eclampsia.
Among these protein serum placental leptin has demonstrated higher levels in pregnant women
who will subsequently develop pre-eclampsia. However, screening performance of leptin
detection in early pregnancy has never been assessed.
Our study is aimed to evaluate the performance of serum leptin measurement in association
with uterine artery Doppler as a screening too for placental insufficiency.
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Observational Model: Case-Only, Time Perspective: Prospective
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