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Fetal Death clinical trials

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NCT ID: NCT06202508 Completed - Clinical trials for Fetal Death in Utero

Fetal Death in Utero in the Internship Experience of Midwifery Students : an Unavoidable Experience?

MFU
Start date: June 18, 2021
Phase:
Study type: Observational

Fetal death in utero and the psychological and professional impact it could have on the midwifery student in training. Fetal death in utero corresponds to the spontaneous cessation of cardiac activity, from 14 weeks of amenorrhea. For a large proportion of midwifery students, fetal death in utero is a situation encountered in the field. Despite the theoretical courses, a student does not expect to encounter this type of situation during the internship: it is delicate for both the supervising caregivers and the student. The purpose of this study is to demonstrate the impact that this situation could have on the midwifery student, both psychologically and in terms of their professional project.

NCT ID: NCT06036576 Completed - Thyroid Diseases Clinical Trials

Thyroxine Therapy for Recurrent Pregnancy Loss in Hypothyroid Women

Start date: March 1, 2022
Phase: Phase 3
Study type: Interventional

The goal of this clinical trial is to investigate the influence of thyroxine supplementation on pregnancy outcomes in women with varying levels of Thyroid-Stimulating Hormone (TSH), who have experienced recurrent pregnancy loss in the first trimester. The main questions it aims to answer are: - Does thyroxine treatment improve pregnancy outcomes in women with TSH levels between 2.5 mU/L and 4 mU/L? - Is the effect of thyroxine treatment different in women with TSH levels higher than 4 mU/L? Participants will be grouped based on their TSH levels, into two groups - those with TSH levels between 2.5 mU/L and 4 mU/L, and those with TSH levels higher than 4 mU/L. They will then be given thyroxine treatment. Researchers will compare these two groups to see if the pregnancy outcomes differ based on the different TSH levels and thyroxine treatment.

NCT ID: NCT05342948 Completed - Clinical trials for Recurrent Pregnancy Loss

Association of HY-restricting HLA Class II Alleles, Sex of Firstborn Child, and Pregnancy Outcome in RPL Patients

Start date: January 1, 2016
Phase:
Study type: Observational [Patient Registry]

This cross-sectional and prospective cohort study will investigate if sRPL patients with a first born boy who carry ≥1 HY-restricting (HY-r) HLA class II alleles are associated with a lower chance for a succesful reproductive outcome in first pregnancy after admission compared to sRPL patients with a first born girl carrying ≥1 HY-r HLA class II alleles and women with no HY-r HLA class II alleles and a firstborn boy. Also, the study will compare sRPL patients with a firstborn boy who do not carry a HY-r HLA class II allele with sRPL patients having a firstborn girl and carrying no such alleles. We hypothesize that sRPL patients with a first born boy compared to sRPL patients with a firstborn girl who carry ≥1 HY-r HLA class II alleles is associated with a negative prognosis, while no association between sex of firstborn child and pregnancy outcome is expected in sRPL carrying no HY-r HLA class II alleles. Neither do we expect an association between pregnancy outcome and carriage of HY-r HLA class II alleles in pRPL patients.

NCT ID: NCT05205044 Completed - Clinical trials for Recurrent Pregnancy Loss

Evaluation of Apelin-13 and Apelin-36 in Women With Recurrent Pregnancy Loss

Start date: January 23, 2022
Phase:
Study type: Observational

Lower Apelin levels are associated with hypertensive disorders with pregnancy, yet no studies investigated its levels in recurrent pregnancy loss

NCT ID: NCT05073978 Completed - Preterm Birth Clinical Trials

B-vitamin Levels and Adverse Pregnancy Outcomes

Start date: December 1, 2020
Phase:
Study type: Observational

This prospective nested case-control study aims to examine the effects of blood vitamin B levels in first-trimester pregnant women on the pregnancy outcomes

NCT ID: NCT04718233 Completed - Clinical trials for Recurrent Pregnancy Loss

Effect of Sildenafil Citrate on Mid Luteal Phase Uterine Artery Blood Flow in Patients With Recurrent Pregnancy Loss

Start date: September 5, 2018
Phase: Phase 2
Study type: Interventional

Patients with recurrent pregnancy loss are known to have decreased uterine artery blood flow. Nitric oxide plays a major role in increasing uterine blood flow during the luteal phase. This study is done to evaluate the effects of sildenafil on blood flow indices in the patients with recurrent pregnancy loss due to impaired uterine artery blood flow.

NCT ID: NCT04549909 Completed - Clinical trials for Pregnancy Loss, Early

Biochemical Pregnancy Loss. A Multicenter Retrospective Study

BPL
Start date: February 12, 2019
Phase:
Study type: Observational

Biochemical pregnancy loss (BPL) is a very frequent issue in human reproduction. After the implantation of the embryo, hCG disappears very soon from the maternal bloodstream and no evidence of a clinical pregnancy is seen. Different studies showed that factors such as age, oocyte and embryo quality, and endometrium receptivity may have something to do with the occurrence of biochemical pregnancy loss post assisted reproduction treatment. The main aim of this study is to evaluate the incidence of biochemical pregnancy loss (BPL) in three different cohort populations; patients undergoing frozen embryo transfer (FET) from own oocytes after preimplantation genetic testing for aneuploidy (PGT-A), patients undergoing FET from own and donated oocytes and with endometrial receptivity array (ERA), and patients undergoing FET from own or donated oocytes (without PGTA or ERA test). We will analyse the incidence of BPL in these populations and try to determine the role of the euploid status embryo in the first group, the endometrium in the second group and the third one as control group. We are waiting to find the value of both players in the origin of BPL.

NCT ID: NCT04455256 Completed - Clinical trials for Recurrent Pregnancy Loss

Evaluation of Endoplasmic Reticulum Stress in Patients With Recurrent Pregnancy Loss

Start date: March 20, 2020
Phase:
Study type: Observational

To evaluate endoplasmic reticulum stress in women with recurrent pregnancy loss and those who had healthy births in the same age group. The level of the unfolded protein X box binding protein 1 (XBP-1) is measured. It is aimed to show the effect of endoplasmic reticulum stress on recurrent pregnancy loss.

NCT ID: NCT04410029 Completed - Clinical trials for Early Pregnancy Loss

Evaluation of a Decision Aid for Early Pregnancy Loss

Start date: July 29, 2020
Phase: N/A
Study type: Interventional

This study aims to determine the effect of the Healthwise decision aid on shared decision making in women undergoing management of early pregnancy loss.

NCT ID: NCT04281368 Completed - Intra-Uterine Death Clinical Trials

Analysis of All Stillbirths in Stockholm County 2017, a Multidisciplinary Audit

Start date: June 1, 2019
Phase:
Study type: Observational

All stillbirths in Stockholm during 2017 were analysed according to the primary outcomes which were preventable/non-preventable deaths and the level of delay. The secondary outcomes were: causes of death, standard of care pre and post stillbirth and if a summary of the possible causes of death was made as well as the planning of supervision of the next pregnancy.