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Ejaculation Abstinence Time and Assisted Reproductive Technology Outcomes

Fertilization in Vitro Clinical Trial

Official title:
The Effect of Reducing Ejaculation Abstinence Time on Assisted Reproductive Technology Outcomes: a Prospective Randomized Controlled Study

Clinical Trial Summary

The goal of this clinical trial is to learn if reducing the ejaculation abstinence time can improve the outcome of assisted reproductive technology. The main questions it aims to answer are: Does reducing the duration of ejaculation abstinence improve the clinical pregnancy rate for in vitro fertilization and intracytoplasmic sperm injection? Does reducing the duration of ejaculation abstinence improve embryo quality in in vitro fertilization and intracytoplasmic sperm injection？ Does reducing the duration of ejaculation abstinence affect pregnancy loss and live birth rates in in vitro fertilization and intracytoplasmic sperm injection? Researchers will compare less than 48 hours of abstinence time to more than 48 hours, to see if less than 48 hours of abstinence time improved in vitro fertilization outcomes Participants will: Control group abstinence for 3-7 days The experimental group ejaculated once on human chorionic gonadotropin trigger day Follow up their in vitro fertilization outcomes

Clinical Trial Description

The goal of this clinical trial is to learn if reducing the ejaculation abstinence time can improve the outcome of assisted reproductive technology. Group A: Experimental group: ejaculation once within 48 hours before the day of egg retrieval. Group B: Control group: ejaculation once within 4-7 days before the day of egg retrieval. There is currently no clear abstinence period for in vitro fertilization, and the usual practice is to refer to the World Health Organization standard for semen testing: abstinence period of 2-7 days.Group A ejaculated once 48 hours before egg retrieval.Group B was the control group, and ejaculation was performed according to the conventional protocol.Most IVF intervals from ovulation initiation to human chorionic gonadotropin trigger day range from 8-11 days, but the fixed time of egg retrieval is 34-37 hours after the trigger day.Therefore, when determining the human chorionic gonadotropin time, it is less than 48 hours before egg retrieval.In the experimental group, male ejaculates once on the trigger day, and can be ejaculated on the second day if ejaculates fail. Follow up their in vitro fertilization outcomes ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06410417
Study type Interventional
Source The First Hospital of Jilin University
Contact Yueying Zhu, Master
Phone 13504308455
Email zhuyueying1974@jlu.edu.cn
Status Recruiting
Phase N/A
Start date May 1, 2024
Completion date August 1, 2025
View Details
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