The Effect of Progesterone on Human Endometrium

Fertility Clinical Trial

Official title:

The Effect of Progesterone Levels on Human Endometrial Transcriptomics During the Implantation Window

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04323683
• Other study ID #: 13/EM/0277
• Status: Completed
• Start date: February 1, 2019
• Est. completion date: July 31, 2019

Study information

• Verified date: March 2020
• Source: University of Nottingham
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study evaluates the relationship between progesterone levels and endometrial gene expression

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: July 31, 2019
• Est. primary completion date: July 31, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Ages 18-35, regular menstrual cycles, the cycle length between 25 and 35 days, body mass index (BMI) between 18 - 25

Exclusion Criteria:

• History of infertility, history of pelvic pain or/and endometriosis, history of pelvic mass, history of hormonal therapy in the last 3 months

Related Conditions & MeSH terms

• Fertility

Intervention

Genetic:
• Microarray
High throughput technique for determining global gene expression of the condition of interest

Locations

Country	Name	City	State
United Kingdom	Queen's medical center	Nottingham

Sponsors (1)

Lead Sponsor	Collaborator
University of Nottingham

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Differentially expressed genes between women with low and normal progesterone	Fold-change and p-value were used to determine differentially expressed genes using Partek software	2 months