Lymphoma Clinical Trial
Official title:
A Prospective Open Randomized Trial on the Efficacy of Gonadotropin-releasing Hormone Agonist Depot-Triptorelin- to Prevent Chemotherapy Induced Premature Ovarian Failure in Lymphoma Patients.
Chemotherapy drugs like alkylating agents are frequently used in various combined regimens
to treat neoplastic and benign diseases. These drugs are definitely associated with
premature ovarian failure (POF), resulting in an important decrease of the long-term quality
of life and an increase of morbidity. A recent study showed that the patients treated by
alkylating agents had a 4.52 fold higher risk to lose their ovarian function compared with
those who were treated by other agents. The rate of POF after treatment ranged from 40 to
80%, according to the age of the patients and the total doses administered.
Young women who experience POF have to face with the prospects of infertility and to
consider years of hormonal replacement therapy. The possibility of minimizing gonadal damage
by administering of protective therapy during chemotherapy represents an attractive option
for these patients.
The aim of this study is to evaluate the protective effect on the ovarian function of the
gonadotropin-releasing hormone agonist (GnRha) administered concomitantly to alkylating
agents. Preliminary data in the literature on animals (rat and monkeys) are promising. Data
in human are, however, highly controversial.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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