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Examine the Possible Association of Hepatic CYP3A Activity and the Susceptibility to Femur Head Necrosis

Femur Head Necrosis Clinical Trial

Clinical Trial Summary

The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.

Clinical Trial Description

Femur head necrosis is one of the major side effects of corticosteroid therapy. Since corticosteroids are metabolized by hepatic cytochrome P-450 (CYP) 3A, a low endogenous activity of this enzyme may contribute to the pathogenesis of ONFH. The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids. ;

Study Design

Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00244400
Study type Observational
Source Osaka City University
Contact
Status Completed
Phase N/A
Start date November 2002
Completion date January 2006
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