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Examining Caffeine as a Treatment for Antidepressant-induced Arousal Dysfunction in Women

Female Sexual Arousal Disorder Clinical Trial

Official title:
Examining Caffeine as a Treatment for Antidepressant-induced Arousal Dysfunction in Women

Clinical Trial Summary

Antidepressants have negative effects on genital arousal function that hinder quality of life and jeopardize medication adherence. Moderate sympathetic nervous system (SNS) activation through exercise has shown promising results for improving antidepressant-induced genital arousal dysfunction. It is feasible that caffeine - an SNS stimulant - could improve antidepressant-induced genital arousal difficulties if ingested prior to sex. The goal of the present pilot study is to examine whether the acute administration of 300mg of caffeine increases genital arousal in women experiencing antidepressant-induced genital arousal difficulties. Women will attend two counterbalanced sessions in which they ingest either 300mg caffeine or placebo. Fifteen minutes after ingestion, they will view an erotic film while their heart rate and genital sexual arousal are measured. Caffeine could serve as a low-cost, widely accessible intervention with minimal side effects if efficacy is shown.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05685407
Study type Interventional
Source University of Texas at Austin
Contact
Status Completed
Phase Phase 1
Start date January 1, 2023
Completion date April 15, 2023
View Details
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