Feeding Patterns Clinical Trial
Official title:
Evaluation of Regional Splanchnic Tissue Oxygenation Measured by NIRS (Near Infrared Spectroscopy) in Preterm Infants Receiving Bolus Versus Continuous Feeding
Early initiation of enteral feeding, achievement of full enteral feeding and cessation of
parenteral nutrition are extremely important in the very premature infant. This way it is
possible to achieve good post-natal growth and developement while minimizing the metabolic
and infectious complications of parenteral feeding.
There isn't much information in literature regarding the impact of enteral feeding on
intestinal blood flow and intestinal regional oxygenation in the preterm infant. There is
also no consensus regarding the best regimen of delivering the enteral nutrition - bolus
feeding or continuous feeding.
The aim of our study is to compare the intestinal regional oxygenation before and after two
feeding regimens - bolus feeding and continuous feeding - in clinically stable preterm
infants born before 32 weeks gestation. The evaluations will be performed using NIRS
technology (Near Infrared Spectroscopy).
The study may help to assess which feeding regimen is gentler to the immature intestines
(i.e. alters less the splanchnic blood flow and oxygenation) and therefore the preferred way
to feed preterm infants.
Early initiation of enteral feeding, achievement of full enteral feeding and cessation of
parenteral nutrition are extremely important in the very premature infant. This way it is
possible to achieve good post-natal growth and developement while minimizing the metabolic
and infectious complications of parenteral feeding.
There isn't much information in literature regarding the impact of enteral feeding on
intestinal blood flow and intestinal regional oxygenation in the preterm infant. There is
also no consensus regarding the best regimen of delivering the enteral nutrition - bolus
feeding or continuous feeding.
The aim of our study is to compare the intestinal regional oxygenation before and after two
feeding regimens - bolus feeding and continuous feeding - in clinically stable preterm
infants born before 32 weeks gestation. The evaluations will be performed using NIRS
technology (Near Infrared Spectroscopy).
The investigators intend to assess 20 clinically stable, appropriate for gestational age
preterm infants, born before 32 weeks of gestation and receiving full enteral feedings at
least 1 week prior to enrollment with no signs of feeding intolerance.
All 20 participants evaluated constitute the 2 study groups:
1. Group 1 = Bolus feeding - before and after one bolus feeding
2. Group 2 = Continuous feeding - before and after one continuous feeding.
The study may help to assess which feeding regimen is gentler to the immature intestines
(i.e. alters less the splanchnic blood flow and oxygenation) and therefore the preferred way
to feed preterm infants.
;
Observational Model: Case-Crossover, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03399617 -
SPOON: Sustained Program for Improving Nutrition - Guatemala
|
N/A | |
| Completed |
NCT03841123 -
Effectiveness of a Dietary Counseling to Prevent Early Consumption of Added Sugar and Ultra-processed Foods
|
N/A | |
| Recruiting |
NCT06083831 -
The Effect of Sequential Feeding for Circadian Rhythm and Gut Flora Rhythm in Critically Ill Patients
|
||
| Completed |
NCT04743960 -
Assessing Metabolic and Sleep Consequences of Overnight Home Parenteral Nutrition
|
N/A | |
| Withdrawn |
NCT04561700 -
Nutritive Sucking Patterns in Premature Infants
|
N/A | |
| Completed |
NCT03349151 -
Postoperative Results of Early Versus On-demand Maternal Feeding After Cesarean Delivery
|
N/A | |
| Enrolling by invitation |
NCT03755999 -
A Cue-based Developmental Approach Toward the Preterm Infants During Feeding Transition Period
|
N/A | |
| Not yet recruiting |
NCT04338737 -
Post Operative Feeding After Cesarean Section
|
N/A | |
| Not yet recruiting |
NCT06447155 -
Continuous Versus Bolus Feeding in Neonates With Hypoxic Ischemic Encephalopathy
|
N/A | |
| Completed |
NCT05845411 -
Mindful Eating for Eating Behavior Individuals Overweight and Obesity
|
N/A | |
| Completed |
NCT05464342 -
Integral Physiological Adaptations to Carbohydrate Periodization
|
N/A | |
| Completed |
NCT02027688 -
Feeding Progression in Preterm Infants
|
N/A | |
| Completed |
NCT01505348 -
Effect of Fasting Versus Feeding on the Bone Metabolic Response to Running
|
N/A | |
| Recruiting |
NCT05525091 -
Neoneur Feeding System Functionality in the Clinic
|
N/A | |
| Completed |
NCT05513495 -
The Effect of Neonatal Feeding Modalities on Splanchnic Oxygenation
|
N/A | |
| Recruiting |
NCT04737200 -
The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU
|
N/A | |
| Completed |
NCT03906409 -
Effect of Nutrient Delivery Pattern on Biological Rhythms in Human Skeletal Muscle
|
N/A | |
| Completed |
NCT01816516 -
Healthy Babies Through Infant Centered Feeding
|
N/A | |
| Recruiting |
NCT05824377 -
To Determine the Best Feeding Practice in Preterm Infants on Non-invasive Ventilation.
|
N/A | |
| Enrolling by invitation |
NCT04400396 -
Effect of Target Fortified Human Milk on the Growth Quality of Very Preterm Infants (TargetFort)
|