Metabonomics of COPD and Transplanting of Faecal Bacteria in the Treatment of Its Malnutrition

Fecal Microbiota Transplantation Clinical Trial

Official title: Metabonomics of Chronic Obstructive Pulmonary Disease and Fecal Microbial Transplantation in the Treatment of Malnutrition

Status Recruiting

Clinical Trial Summary

Oxidative stress can affect the balance of intestinal flora and intestinal structure of patients, resulting in intestinal flora disorder. Its bacterial metabolites stimulate the parasympathetic nerve, regulate insulin secretion and other metabolic pathways of patients through neuroendocrine regulation, resulting in abnormal energy metabolism of lipids and sugars in the digestive tract, and finally lead to malnutrition.We hypothesized that fecal bacteria transplantation could reconstruct the normal intestinal flora, restore the intestinal digestion and absorption function of chronic obstructive pulmonary disease（COPD）patients and improve the state of malnutrition.

Clinical Trial Description

1. improve the COPD patients with malnutrition is the key to improve the digestion and absorption function of chronic obstructive pulmonary disease (COPD) is one of the world's third most common cause of death, is characterized by progressive airflow limited, mainly by the long-term exposure to tobacco smoke and other harmful air pollutants.

It has been reported that 20%-71% of COPD patients suffer from malnutrition, and there is a negative correlation between BMI and prognosis.

There is increasing evidence that patients with COPD with lower BMI or fat-free mass index are associated with poorer prognosis and impaired long-term survival.

At present, nutrition supplements are mainly used to solve the problem of COPD malnutrition, including vitamins and minerals, essential amino acids and biological amino acids, anti-inflammatory omega-3, high fat and high carbohydrate, etc., while the causes of COPD malnutrition and the relationship between COPD and metabolism have not been paid attention to.

Although there is evidence that there is no malnutrition nutritional support can improve the prognosis of patients with COPD, but exist in patients with malnutrition, due to impaired digestion and absorption, increase nutrition supply, prone to patients with abdominal distension, vomiting, and diarrhea.

Therefore, in order to improve malnutrition in patients with COPD, it is necessary to improve digestion and absorption function in patients with COPD.

2. improve digestion and absorption function, first of all, correct the oxidative stress caused by intestinal flora disorder as part of the systemic oxidative stress response, copd patients with intestinal oxidative stress, oxidative stress result of active oxygen free radicals on colon epithelium mucosa layer of mucin, lead to the loss of protein, mucous layer thickness can be reduced to 50%, resulting in changes in the structure of intestinal tract; In addition, under the action of active oxygen free radicals, epithelial cells of the digestive tract, the close connection between protein oxidation lead to intestinal epithelial permeability enhancement, on the one hand, the intestinal toxins can after connection into the intestinal permeability increased cells, affect the digestion and absorption function of intestinal cells, on the other hand, the oxidative stress products into the lumen of blood, lead to bacterial flora disorder, further affect intestinal digestion and absorption of food.

The common clinical manifestations of intestinal flora disorder are: mild abdominal distension, diarrhea, nausea, vomiting, water and electrolyte disturbance, hypoproteinemia, malnutrition, and even shock. Therefore, in order to improve intestinal digestion and absorption function, it is necessary to correct intestinal flora disorder caused by oxidative stress.

3. intestinal flora and the relationship between nutrition, immunity, metabolism, neuroendocrine, normal human intestinal bacteria number, up to about 1013 ~ 1014 microbes, equivalent to 10 times of the total number of human tissue cells and its metabolites other tissue cells function to human body impact, the total number of genes at the same time, the intestinal bacteria coding is about more than 100 times of the total number of human genes, some experts believe that intestinal flora is one of the normal function of the human body organ, the abnormal organs, inevitably affects the health of human body.

Intestinal flora by helping to break down food and absorb nutrition, synthesis of nutrients, metabolites indirectly stimulate the nerve endocrine effects such as the host's nutritional status: promote ingested B vitamins (B3, B5, B6, B12) and other micronutrients, help absorb minerals (calcium, magnesium and iron, etc.), regulating metabolism of glucose and lipid storage.

Synthesis of micronutrients such as vitamin K, B12, biotin, folic acid and pantothenates; By affecting the integrity of mucosal epithelium, it plays an immune defense role.

Intestinal flora disturbance is related to the formation of metabolic diseases such as obesity and diabetes in the host. Rachels study showed that intestinal flora disturbance in rats can increase the production of acetate, and feeding acetate to rats can promote the secretion of insulin in rats, the mechanism of which is realized by the activation of acetate through the parasympathetic nerve.

The production of acetate increases, and the stimulation intensity of parasympathetic nerve is enhanced, which promotes insulin secretion, and promotes ghrelin secretion by consuming glucose and reducing hypoglycemia, leading to obesity.

A recent study also showed that the intestinal microbiome shifted from lean donors to patients with metabolic syndrome, resulting in increased insulin sensitivity of the receptors.4) animal models and patients with copd, there exist dysbacteriosis. ;

Related Conditions & MeSH terms

• Fecal Microbiota Transplantation
• Malnutrition

• NCT number: NCT04861649
• Study type: Interventional
• Source: Shanghai Asclepius Meditec Inc.
• Contact: Zeguang Zheng
• Phone: 18928868242
• Email: zheng862080@139.com
• Status: Recruiting
• Phase: N/A
• Start date: March 9, 2021
• Completion date: December 30, 2023