Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00557869
Other study ID # CMR-02-TECH-01
Secondary ID
Status Completed
Phase N/A
First received November 13, 2007
Last updated December 18, 2011
Start date October 2002
Est. completion date September 2011

Study information

Verified date December 2011
Source Medical University of Graz
Contact n/a
Is FDA regulated No
Health authority Austria: Ethikkommission
Study type Observational

Clinical Trial Summary

The aim of the present study is the optimization of various magnetic resonance (MR) investigation protocols of the heart and the lung without contrast agent application as well as the generation of normal values from cardiac MR images. One of the main problems in cardiac MR investigations is the strong dependence of the achieved image quality on optimal settings of sequence parameters and anatomical and physiological situations with special emphasis on phase-contrast imaging and other cine-techniques.


Description:

Time optimized and well organized MR protocols for the cardiac and lung investigations are evaluated on normal subjects with special respect to following topics:

1. Localization: Definition of standardized anatomic imaging planes with special respect to the right ventricle.

2. Morphological imaging: Optimization of spin-echo and gradient-echo sequences for various heart frequencies and breath-hold abilities. Investigation of the effect of various preparation pulses. Optimization of the signal-to-noise ratio for morphological cardiac imaging. Evaluation and optimization of various breathing and breath-hold (with and without navigator) ECG and pulse triggered sequences.

3. Cardiac and lung function: Optimization of gradient-echo sequences for various heart frequencies and breath-hold abilities. Evaluation of pulse-triggered function analysis and optimization of free breathing protocols. Optimization of tagging techniques. Evaluation of the pulsatile flow in lung vessels. Acquisition of age depended normal data of cardiac and lung function.

4. Coronary imaging: Definition of standardized anatomic imaging planes to monitor coronary arteries (single oblique, volume targeted). Optimization of acquisition window with respect to various heart frequencies. Evaluation of the influence of the position of the navigator and tracking factor on image quality. Optimization of a pulse triggered protocol. Evaluation of black-blood coronary imaging and visualization of the lumen and wall of coronary arteries.

5. Phase contrast techniques: Optimization of imaging planes, time resolution and spatial resolution of flow measurements in the heart, in the vessels around the heart, lung vessels and coronary arteries. Evaluation of retrospective and prospective gating with respect to the heart frequency. Evaluation of normal values in 1-dimensional, 2-dimensional and 3-dimensional time resolved flow measurements.

6. Single-Shot Imaging: Evaluation of signal intensity and stability of single shot techniques with and without preparation pulses. Optimization of real-time image acquisition.

7. Parallel acquisition and breath-hold time optimization: Evaluation of impact of echo-sharing and parallel acquisition on image quality. Optimization of short-breath-hold protocols.


Recruitment information / eligibility

Status Completed
Enrollment 122
Est. completion date September 2011
Est. primary completion date September 2011
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 16 Years and older
Eligibility Inclusion Criteria:

- No history of cardiac or pulmonary diseases

Exclusion Criteria:

- MRI exclusion criteria

Study Design

N/A


Locations

Country Name City State
Austria Medical Unitersity Graz, Allgemeine Radiologische Diagnostik Graz Stmk

Sponsors (1)

Lead Sponsor Collaborator
Medical University of Graz

Country where clinical trial is conducted

Austria, 

References & Publications (3)

Reiter G, Reiter U, Bergmann P, Rienmüller R. MR imaging-based port placement planning for totally endoscopic coronary artery bypass grafting. Interact Cardiovasc Thorac Surg. 2004 Jun;3(2):341-5. — View Citation

Reiter G, Reiter U, Kovacs G, Kainz B, Schmidt K, Maier R, Olschewski H, Rienmueller R. Magnetic resonance-derived 3-dimensional blood flow patterns in the main pulmonary artery as a marker of pulmonary hypertension and a measure of elevated mean pulmonar — View Citation

Reiter G, Reiter U, Rienmüller R, Gagarina N, Ryabikin A. On the value of geometry-based models for left ventricular volumetry in magnetic resonance imaging and electron beam tomography: a Bland-Altman analysis. Eur J Radiol. 2004 Nov;52(2):110-8. — View Citation

See also
  Status Clinical Trial Phase
Recruiting NCT05863559 - Super Chef - an Online Program Promoting the Mediterranean Dietary Pattern to Lower Income Families N/A
Completed NCT04169724 - Meditation for Burnout in PA Students N/A
Active, not recruiting NCT04505345 - Virtual Reality Cognitive Training in Alcohol Use Disorder N/A
Completed NCT03286192 - Compassion Cultivation Training for Nurses N/A
Recruiting NCT06322199 - Differences Between Suicide Attempters and Suicide Ideators. Influence of the Brief Therapy Attempted Suicide Short Intervention Program (ASSIP) on Neuropsychological Correlates and Psychological Process Factors - Project 3
Not yet recruiting NCT05790343 - Feasibility Study: Being a Parent - Helping Your Child With Fears and Worries
Terminated NCT05503810 - Social Support Intervention Targeting Patients Treated for Cardiac Disease Who Experience Loneliness N/A
Completed NCT04150354 - Mental Health Symptom Monitoring Utilizing the Cogito Behavioral Analytic Platform N/A
Active, not recruiting NCT06175520 - Introduction of Preconception Care Through Public Health System for Improving MNCH&FP N/A
Completed NCT06371248 - Steady Feet: Preventing Falls in the Community N/A
Completed NCT06063252 - Newly Diagnosed With Inflammatory Arthritis - a Self-management Intervention (NISMA) N/A
Recruiting NCT05737823 - Supporting Family Carers' Mental Health N/A
Terminated NCT03503968 - TCR Modified T Cells MDG1011 in High Risk Myeloid and Lymphoid Neoplasms Phase 1/Phase 2
Not yet recruiting NCT04305990 - Demand-Driven Method for Gas Delivery in a Dental Setting N/A
Completed NCT04553159 - Autologous Adipose Derived Stem Cells Transplantation in the Treatment of Keloids. Phase 2
Completed NCT05697887 - Feasibility, Tolerability and Efficacy of the Ketogenic Diet in Children With Drug-resistant Epilepsy in South Vietnam N/A
Completed NCT03237871 - The EMERGE Project: Feasibility of Assessing Economic and Sexual Risk Behaviors Using Text Messages in Young Adults N/A
Not yet recruiting NCT06087718 - Feasibility of the Maastro Applicator in Rectal Cancer N/A
Active, not recruiting NCT01902238 - EUS-guided Ethanol-lipiodol Ablation of Pancreatic Neuroendocrine Tumor: a Prospective Study N/A
Completed NCT01398059 - The Metabolic Effects of Breaks in Sedentary Time N/A