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NCT00302978 Clinical Trial

Changes in Brain Activity (Functional MRI Study) Before and After Behavioral Therapy of Height Phobia

Fear of Heights Clinical Trial

Official title:
The Effects of in Vivo Exposure Therapy on the Neural Correlates of Height Phobia: a Functional Magnetic Resonance Imaging Study Using a Fear Provocation Paradigm.

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00302978
Other study ID # 5215
Secondary ID
Status Completed
Phase N/A
First received March 14, 2006
Last updated December 14, 2011
Start date March 2006
Est. completion date June 2006

Study information
Verified date April 2007
Source New York State Psychiatric Institute
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Interventional

Clinical Trial Summary

We are interested in investigating the functional brain abnormalities of height phobia. Subjects will be have a functional MRI scan before and after a course of treatment with behavioral therapy.

Description:

The purpose of this study is to investigate the effects of in vivo exposure therapy on the functional brain activity of subjects with height phobia using a fear provocation paradigm. We expect differential activation of the fear circuitry in height phobics compared to non-phobic controls, and that successful behavioral therapy will normalize the heightened fear response in height phobia.

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date June 2006
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria:

- Specific phobia of Heights

Exclusion Criteria:

- History of medical problems

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Behavioral:
• Behavior therapy

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
New York State Psychiatric Institute

Outcome
Type Measure Description Time frame Safety issue
Primary CGI
Secondary acrophobia questionnaire
See also
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Completed NCT03907345 - Generalized Fear Extinction to Untreated Fear Stimuli in Specific Phobias After Exposure N/A
Enrolling by invitation NCT05824884 - Self-efficacy Enhancement in a Virtual Reality Training for Fear of Heights N/A
Completed NCT04737915 - Virtual Reality Exposure Versus In Vivo Exposure for Fear of Heights N/A
Completed NCT04975854 - Virtual Reality Exposure Therapy for Acrophobia N/A
Completed NCT02361203 - Exercise and Virtual Reality Exposure Therapy for Acrophobia N/A
Suspended NCT03917433 - Augmenting Virtual Reality Exposure Therapy for Acrophobia N/A