Fatty Liver Clinical Trial
Official title:
Anthropometric Evaluation and Body Composition in Sedentary Postmenopausal Women With Nonalcoholic Fatty Liver Disease (NAFLD) Submitted to Physical Activity
Were included 40 patients with NAFLD followed at the Ambulatory of Non-alcoholic Fatty Liver
Disease , Discipline of Clinical Gastroenterology, Clinic Hospital of the Medical School of
the University of Sao Paulo (HC-FMUSP). Were included adults women of any race, aged 35 to
75 years, diagnosed with NAFLD and were followed for a period of six months. All patients
underwent anthropometric and body composition, as well as analysis of clinical, laboratory
before and after 6 months of exercise training protocol established.
The hypothesis of our research is that aerobic activity had a favorable impact on NAFLD. It
is expected that the intervention of physical activity causes a decrease or no weight,
decreased levels of aminotransferases, decreased insulin resistance assessed by homeostasis
model assessment (HOMA) index and consequently decrease or reversal of hepatic steatosis.
The Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver diseases,
affecting approximately 20-30% of the adult population and is more common in obese
individuals (70-80%). The main risk factors associated with the disease are the components
of the Metabolic syndrome. To date, there is no specific pharmacological treatment for NAFLD
and changes in lifestyle with weight reduction and exercise are always recommended. Few data
exist on the impact of physical activity and optimal nutritional strategy for the treatment
of NAFLD. Seen the need to elucidate the impact of physical activity and the search for an
ideal nutritional strategy in the treatment of NAFLD, the investigators proposed a
randomized controlled trial evaluating the effects of a hypocaloric high-protein diet and
aerobic exercise associated with this diet on metabolic and anthropometric parameters in
sedentary postmenopausal women. 40 sedentary postmenopausal women with NAFLD who had liver
biopsy for a period equal to or less than 2 (two) years were included. These patients were
randomized into 2 groups: TRAINING group (19): aerobic training with hypocaloric
high-protein diet and DIET group (21): only hypocaloric high-protein diet, and followed for
a period of six months.
Laboratorial Assays (baseline and end of the protocol)
- AST, ALT, FA, GGT, albumine, Fe, fasting glucose, insulin, Total cholesterol, HDL, LDL,
Triglycerides;
- TNFalfa, IL6, and adiponectin.
Anthropometrical Evaluation (baseline and end of the protocol)
- BMI, waist circumference, percent body fat, body fat mass, lean body mass
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Outcomes Assessor), Primary Purpose: Treatment
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