Fatty Liver Clinical Trial
Official title:
Growth Hormone Replacement in Adults With Growth Hormone Deficiency (GHD) - The Effect on Liver Fat.
We will examine a cohort of growth hormone deficient adults starting growth hormone (GH)
replacement. The purpose of this study is to determine whether GH replacement reduces the fat
content of the liver.
To compare the results we will include growth hormone deficient patients who do not start GH
replacement as controls.
Adults with untreated growth hormone deficiency (GHD), a condition mostly due to pituitary
disease, often show metabolic features similar to those described in the 'metabolic
syndrome'. Growth hormone (GH) replacement has been shown to reverse many of these
unfavorable changes, with a particular evident reduction of visceral fat. In recent years, a
strong correlation between fat accumulation in the liver and features of the metabolic
syndrome (particularly visceral fat) has been identified, and 'fatty liver' is now being
referred as the hepatic feature of the 'metabolic syndrome'. The effect of GH replacement on
liver fat, however, has never been systematically studied.
We will assess 15 patients with GHD before and 6 months after starting GH replacement. We
will also assess 15 control patients with GHD but who don't go on GH replacement for various
reasons.
Liver fat will be assessed using MR spectroscopy. Changes in liver fat will be correlated to
changes in insulin sensitivity and changes in various inflammatory markers.
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