Fatty Liver Clinical Trial
Official title:
Prospective Observational Study
Non alcoholic fatty liver disease (NAFLD) is one of the main causes of development of
chronic liver disease and cirrhosis. There are no published studies which have investigated
the incidence of NAFLD in pregnant women or the correlation between the metabolic changes in
pregnancy and this phenomenon.
We aimed in our study to explore the incidence of NAFLD in pregnancy by ultrasonography (US)
during the end of the pregnancy or immediately after birth (after 36 weeks) and to look for
a correlation between fatty liver and demographic, clinical, nutritional and laboratory data
during pregnancy.
Fatty liver in pregnancy-protocol:
Non alcoholic fatty liver disease (NAFLD) is one of the main causes of development of
chronic liver disease and cirrhosis. The incidence of NAFLD among the general population is
about 17-30%. There are no published studies which have investigated the incidence of NAFLD
in pregnant women or the correlation between the metabolic changes in pregnancy and this
phenomenon.
We aimed in our study to explore the incidence of NAFLD in pregnancy by ultrasonography (US)
during the end of the pregnancy or immediately after birth (after 36 weeks) and to look for
a correlation between fatty liver and demographic, clinical, nutritional and laboratory data
during pregnancy.
Methods: US examination will be performed by an experienced technician. The liver will be
scanned by B mode US using a 2-5 MHZ transducer. In those with fatty liver as seen by US, a
repeat examination will be performed after 6 weeks and 24 weeks. For women with the
diagnosis of fatty liver, serum lipid profile, glucose, liver function tests and insulin
will be done. Homa score as well as BMI will be calculated for each woman with fatty liver.
All participants will sign an informed consent which has been approved by the hospital
ethical committee.
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Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Cross-Sectional
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