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Fatty Liver clinical trials

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NCT ID: NCT02337894 Not yet recruiting - Insulin Resistance Clinical Trials

Effects of Amino Acid Supplementation on Liver Lipid Content and Protein Metabolism in Obese Children

Start date: January 30, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the effect of an eight-week dietary supplementation with essential amino acids plus arginine on liver and plasma lipid content, whole-body fat oxidation, whole-body insulin sensitivity, whole body protein metabolism, and body composition in obese pre-pubertal children.

NCT ID: NCT02337660 Completed - Clinical trials for Non-alcoholic Fatty Liver Disease

Involvement of Steatosis-induced Glucagon Resistance in Hyperglucagonaemia

Start date: January 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to examine whether non-alcoholic fatty liver disease (NAFLD) is associated with hepatic glucagon resistance and hyperglucagonemia.

NCT ID: NCT02330549 Completed - Clinical trials for Type 2 Diabetes Mellitus

ORION: Effects of Cenicriviroc on Insulin Sensitivity in Subjects With Prediabetes or Type 2 Diabetes Mellitus (T2DM) and Suspected NAFLD

Start date: July 17, 2015
Phase: Phase 2
Study type: Interventional

A Phase 2a, randomized, double-blind, placebo-controlled, multi-center study of cenicriviroc (CVC) to be conducted in approximately 50 adult obese subjects [body mass index (BMI) ≥ 30 kg/m^2] with prediabetes or type 2 diabetes mellitus and suspected NALFD.

NCT ID: NCT02329405 Completed - Clinical trials for Non-alcoholic Fatty Liver Disease

The Effects of PXR Activation on Hepatic Fat Content

Start date: December 2014
Phase: Phase 4
Study type: Interventional

This study investigates the effects of pregnane X receptor (PXR) activation on hepatic fat content in healthy volunteers. Rifampicin (an antibiotic and also an efficient PXR activator) and placebo will be given for a week to volunteers. Hepatic fat content is measured with magnetic resonance imaging and blood samples are collected at the end of each study arm. The investigators' hypothesis is that rifampicin causes accumulation of fat to the liver.

NCT ID: NCT02316717 Completed - Clinical trials for Non-alcoholic Steatohepatitis (NASH)

A Phase ll Study of IMM-124E for Patients With Non-alcoholic Steatohepatitis

Start date: December 2014
Phase: Phase 2
Study type: Interventional

This study will evaluate the safety and preliminary efficacy of two dose levels of IMM-124E in reducing liver fat and/or serum alanine aminotransaminase (ALT) compared with placebo.

NCT ID: NCT02314026 Completed - Clinical trials for Non-Alcoholic Steatohepatitis

BREATHID Octanoate Breath Test With or Without Methacetin Breath Test for Correlation With Biopsy in NASH

Start date: March 2015
Phase: Phase 2
Study type: Interventional

This study's aim is to develop an algorithm for the ¹³C-Octanoate Breath Test with or without the ¹³C-Methacetin Breath Test (OBT and MBT respectively) for correlation with histological findings associated with of Non-Alcoholic Steatohepatitis (NASH) and other liver diseases using the BreathID® System

NCT ID: NCT02307344 Not yet recruiting - Clinical trials for Nonalcoholic Steatohepatitis

Effect of Nigella Sativa on Nonalcoholic Steatohepatitis and Steatosis

NASH NAFLD
Start date: January 2015
Phase: N/A
Study type: Interventional

The investigators hypothesize that Nigella Sativa will have an effect on Nonalcoholic Steatohepatitis and Liver Steatosis by enhancing lipophagy in the liver tissue.

NCT ID: NCT02303730 Completed - Clinical trials for Diabetes Mellitus, Type 2

Exenatide Compared With Insulin Glargine to Change Liver Fat Content in Type 2 Diabetes

Start date: March 2015
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate whether exenatide is superior to insulin glargine (after 24 weeks) in reducing liver fat content (by MRS) in patients with newly diagnosed type 2 diabetes mellitus and concomitant non-alcoholic fatty-liver disease(NAFLD).

NCT ID: NCT02303314 Completed - Clinical trials for Non-alcoholic Fatty Liver Disease

Efficacy of Oral Trigonella Foenum-graecum Seed Extract Vs Placebo in Treatment of None Alcoholic Fatty Liver Disease

Start date: November 2014
Phase: Phase 2/Phase 3
Study type: Interventional

This study design to examine performance of trigonella foenum-graecum (TFG) in treatment of non-alcoholic fatty liver disease. Base on inclusion and exclusion criteria, 50 patients select and then randomize into intervention and control groups. Two group use capsules which contain TFG or placebo, respectively.

NCT ID: NCT02298439 Recruiting - Clinical trials for Non-Alcoholic Fatty Liver Disease

Fatty Liver Patient Registry

Start date: October 2013
Phase:
Study type: Observational [Patient Registry]

The purpose of the Non-Alcoholic Fatty Liver Disease (NAFLD) registry is to collect demographic and clinical data on patients being treated for NAFLD and to determine the factors affecting the progression of the disease as well as the success of different treatment strategies.