Satiety Effects on the Neural Valuation of Food

Fasting Clinical Trial

Official title:

Functional Magnetic Resonance Imaging Study of the Valuation of Food as a Function of Satiety

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01721187
• Other study ID #: VOFIO3G
• Status: Completed
• Phase: N/A
• First received: October 23, 2012
• Last updated: August 4, 2015
• Start date: October 2012
• Est. completion date: July 2014

Study information

• Verified date: August 2015
• Source: Duke-NUS Graduate Medical School
• Contact: n/a
• Is FDA regulated: No
• Health authority: Singapore: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

Using fMRI, this study will explore the neural correlates of satiety when individuals make decisions about food. The investigators will also examine individual differences in satiety effects.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: July 2014
• Est. primary completion date: December 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 21 Years to 45 Years

Eligibility

Inclusion Criteria:

• Chinese ethnicity

• 21 to 45 years old

• English as first language

• Right-handed

• Have normal eyesight, or have long-sightedness or myopia within +8.0 to -8.0 diopters (unless corrected by contact lenses)

• Weigh less than 100kg with an abdominal circumference of less than 120cm

• Non-smoker, or only smoke occasionally (less than 5 sticks a week)

• Consume less than 2 units (200 mg) of caffeine a day

• Consume less than 21 units of alcohol per week (e.g. 500ml 5% beer = 2.5 units, 250ml 14% wine = 3.5 unit)

• Habitually sleep before 1am and wake before 9am

Exclusion Criteria:

• On a restrictive diet (e.g., vegetarian/vegan diet)

• History of food allergies

• History of psychiatric or neurological disorders

• History of chronic medical illness

• Metal implants in or on the body (e.g. braces, dental retainers, pacemakers)

• Shift worker

• Claustrophobic

• High astigmatism (high = >2.00 diopters)

• Colour-blind

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Fasting
• Fed

Locations

Country	Name	City	State
Singapore	Centre for Cognitive Neuroscience scanner suite	Singapore

Sponsors (2)

Lead Sponsor	Collaborator
Duke-NUS Graduate Medical School	Singapore Institute for Clinical Sciences

Country where clinical trial is conducted

Singapore, 

References & Publications (2)

Knutson B, Westdorp A, Kaiser E, Hommer D. FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage. 2000 Jul;12(1):20-7. — View Citation

Plassmann H, O'Doherty J, Rangel A. Orbitofrontal cortex encodes willingness to pay in everyday economic transactions. J Neurosci. 2007 Sep 12;27(37):9984-8. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	fMRI - Willingness to Pay task (BDM auction)	A measurement of how much participants are willing to pay for foods and non-foods, as an assay for subjective value of goods.	Fed and fasted visits (Wks 1 & 2)	No
Primary	fMRI - Monetary and Food Incentive Delay task	A measurement of neural response to anticipating and receiving money and food rewards.	Fed and fasted visits (Wks 1 & 2)	No