Treatment With High Dose Methotrexate in Patients With Eosinophilic Fasciitis

Fasciitis Clinical Trial

Official title: Treatment With High Dose Methotrexate in Patients With Eosinophilic Fasciitis

Status Completed

Clinical Trial Summary

Evaluate the effect of high dose MTX on skin induration in patients with eosinophilic fascia.

Clinical Trial Description

Eosinophilic fasciitis (EF)is a fibrosing skin disorder extensively involving the deep fascia. The aim of this pilot study is to evaluate the effect of high dose MTX on skin induration in patients with EF. In addition, we study the effect of this treatment on joint mobility, peripheral blood eosinophilia, functional ability, and pulmonary function. By administering high dose MTX intravenously every four weeks with a Leukovorin rescue, we hope to induce a more pronounced and sustained effect on the involved skin with less (long-lasting) side effects. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Eosinophilia
• Fasciitis

• NCT number: NCT00441961
• Study type: Interventional
• Source: Radboud University
• Status: Completed
• Phase: N/A
• Start date: October 2006
• Completion date: June 2011