Fasciculation Clinical Trial
Official title:
Effects of Cisatracurium on Succinylcholine-induced Fasciculations and Myalgia
The purpose of this study is to investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations and postoperative myalgia.
Purpose: To investigate the effects of different doses of cisatracurium pretreatment on
succinylcholine-induced fasciculations and postoperative myalgia.
Methods: Ninety patients scheduled for laparoscopic cholecystectomies were equally
randomized into three groups to receive pretreatment of 0.005, 0.01, and 0.02 mg/kg
cisatracurium, respectively. General anesthesia was induced 3.5 min later, train of four
stimulation was monitored 4.5 min later, succinylcholine 1.5 mg/kg was injected 5 min later,
and endotracheal intubation was implemented 6.5 min later. The side effects of
cisatracurium, intensity of fasciculations, intubating conditions, time and extent to
maximal depression of twitch and time for its recovery to 20% of control value, severity of
myalgia at 24 h postoperatively, serum potassium before the induction, at the time of
endotracheal intubation, and 5 min after intubation were recorded.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT03338114 -
Study to Evaluate the Safety & Efficacy of FLX-787-ODT to Treat Fasciculations in Tongue and Upper or Lower Extremity Muscles Most Affected in Subjects With ALS
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05760976 -
Median Effective Dose of Cisatracurium for the Prevention of Fasciculation Caused by the Injection of Succinylcholine
|
N/A | |
| Terminated |
NCT03334786 -
Study to Evaluate Safety & Efficacy of FLX-787-ODT to Treat Fasciculations in Tongue and Appendicular Muscle in Adult Subjects With ALS
|
Phase 1/Phase 2 |