Fanconi Anemia Clinical Trial
Official title:
Analysis of Fanconi Anemia Gene Function by Microarray Analysis of Bone Marrow Cells
RATIONALE: Studying samples of bone marrow from patients with Fanconi anemia and from healthy
participants in the laboratory may help doctors learn more about changes that occur in DNA
and identify biomarkers related to Fanconi anemia.
PURPOSE: This laboratory study is evaluating gene function in bone marrow cells from patients
with Fanconi anemia and from healthy participants.
OBJECTIVES:
- Describe the complete hematopoietic transcriptomes of Fanconi cells of every common
complementation group (e.g., A, C, G, and F) as well as transcriptomes of neoplastic
cells derived from bone marrow of patients with Fanconi anemia.
- Define large-scale dynamic gene expression data in these patients.
OUTLINE: This is a multicenter study.
Patients and healthy volunteers undergo bone marrow aspiration or biopsy for biological
studies. Samples are analyzed for gene expression profiles using microarray assays.
PROJECTED ACCRUAL: A total of 80 patients and 10 healthy volunteers will be accrued for this
study.
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