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A Diagnostic Test for Familial Mediterranean Fever — DEPIST-FMF  

Familial Mediterranean Fever Clinical Trial

Official title:
Assessment of a Functional Test to Detect Familial Mediterranean Fever

Clinical Trial Summary

Familial Mediterranean Fever (FMF) is the most common auto-inflammatory disease (prevalence: 1-5 / 10,000 inhabitants). It is due to mutations of the MEFV gene, encoding variants of the Pyrin inflammasome. Inflammasomes are protein complexes of innate immunity producing pro-inflammatory cytokines (interleukin-1β). In vitro, preliminary results demonstrated that activation of the Pyrin inflammasome (measured by interleukin-1β concentration) by kinase inhibitors is significantly increased in FMF patients compared to subjects with a similar clinical picture, and healthy controls. In addition, a measure of cell death yielded significant results in differentiating patients from controls. The investigators hypothesize that this fast and simple functional test can serve as a diagnostic tool for FMF.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03747315
Study type Observational
Source Hospices Civils de Lyon
Contact
Status Completed
Phase
Start date December 15, 2018
Completion date December 15, 2020
View Details
See also
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