Familial Mediterranean Fever Clinical Trial
Official title:
Exertional Muscle Fatigue In FMF Patients Evaluated By MRI And MR Spectroscopy Of The Thigh
Familial Mediterranean fever (FMF) is an inherited disorder of unknown etiology,
characterized by recurrent episodes of fever, peritonitis and/or pleuritis.
Fever is the cardinal manifestation of FMF and is present in most attacks accompanied by
abdominal pain.
Another clinical manifestation in patients with FMF is exertional muscle pain, usually in
the thigh, which appears even after minor exercise or physical activity in young patients
with generally good health (other than FMF) and in good physical condition. Some patients
also complain of ankle edema after relatively minor physical activity, which subsides after
a night rest. Although these manifestations are quite common in FMF patients and form part
of the minor criteria for the diagnosis, the etiopathogenesis has not been examined.
The purpose of the suggested study is to evaluate and characterize the anatomical and
biochemical changes in the muscles of the thigh and in the ankle triggered by physical
activity in FMF patients complaining of exertional lower leg myalgias and edema after minor
physical exercise.
n/a
Observational Model: Cohort, Time Perspective: Cross-Sectional
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