Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT03549637 |
Other study ID # |
RC17_0468 |
Secondary ID |
|
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
August 22, 2018 |
Est. completion date |
March 17, 2021 |
Study information
Verified date |
September 2021 |
Source |
Nantes University Hospital |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
The links between low LDL-C levels and psychologic symptoms (psychotic disorders, mood
disorders, aggressivity, suicidal risk, etc.) and cognitive deficits (mainly executing
functioning) are debated. The PARTITION study aims at estimating the prevalence of
hypobetalipoproteinemia (HBL), defined as a LDL-C level ≤ 0,50 g/L, in a psychiatric
population.
Description:
Some forms of hypobetalipoproteinemia (HBL) are associated with a longevity syndrome and
cardiovascular protection due to prolonged exposure to low levels of LDL-C. However, while
LDL-C reduction has been studied extensively for its beneficial effect on cardiovascular
risk, other studies have reported that low levels of LDL-C (either spontaneous or
artificially occurring with low-fat diets or lipid-lowering drugs) may be associated with
psychiatric symptoms (psychotic or mood disorders, aggression, suicidal attempts, etc.) or
altered cognitive performance (particularly executive functioning). These studies have led to
contradictory results, and the possible link between low LDL-C levels and psychiatric
symptoms remains highly controversial so far.
The PARTITION study aims at estimating the prevalence of hypobetalipoproteinemia (HBL),
defined as a LDL-C level ≤ 0,50 g/L, in a psychiatric population. Moreover, the study
includes the characterization of psychiatric disorders as well as psychological and personal
characteristics associated with HBL. The evolutionary profile of patients with and without
HBL will be studied. Genetic characteristics and biomarkers of HBL will also be studied.