Postprandial Lipid Metabolism in Familial Hypercholesterolaemia:Effects of Fish Oils — FIFH  

Familial Hypercholesterolaemia Clinical Trial

Official title: Effect of Fish Oil Supplementation on Postprandial Lipid Metabolism in Familial Hypercholesterolaemia

Status Not yet recruiting

Clinical Trial Summary

The purpose of this study is to determine whether fish oil supplementation is effective in the treatment of abnormal fat metabolism in subjects with elevated cholesterolaemia.

Clinical Trial Description

The use of statin therapy in familial hypercholesterolaemia (FH) is known to reduce cardiovascular risk and is a first line recommendation, however, there is considerable residual risk predicted by the presence of fasting and post-prandial hypertriglyceridaemia.

This study will examine the effect of oral n-3 fatty acid ethyl esters supplementation (4g/day, Omacor) on postprandial hypertriglyceridaemia and post-prandial arterial function when administrated to FH patients at increased risk of cardiovascular disease due to their residual fasting hypertriglyceridaemia. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Familial Hypercholesterolaemia
• Hypercholesterolemia
• Hyperlipoproteinemia Type II
• Hypertriglyceridaemia
• Hypertriglyceridemia

• NCT number: NCT01577056
• Study type: Interventional
• Source: The University of Western Australia
• Contact: Dick Chan, PhD
• Phone: 61-8-92240268
• Email: dick.chan@uwa.edu.au
• Status: Not yet recruiting
• Phase: N/A
• Start date: April 2012
• Completion date: March 2014