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Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis — PreDuoFAP  

Familial Adenomatous Polyposis Clinical Trial

Official title:
Prevention of Progression of Duodenal Adenomas to Cancer in Patients With Familial Adenomatous Polyposis (FAP)

Clinical Trial Summary

Duodenal carcinomas are the leading cause of mortality in patients with Familial Adenomatous Polyposis (FAP) who underwent prophylactic colorectal surgery. The purpose of this study is to determine wether celecoxib combined with ursodeoxycholic acid is an effective chemoprevention strategy to influence the progression of duodenal adenomas to carcinomas in patients with FAP.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00808743
Study type Interventional
Source Radboud University
Contact
Status Completed
Phase Phase 2/Phase 3
Start date May 2009
Completion date January 2013
View Details
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