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Clinical Trial Summary

This is a prospective, randomized control trial in which each patient will be randomly assigned to receive either extended half-life factor VIII based replacement therapy or non-FVIII based replacement therapy, which are both standard of care treatment for persons with Hemophilia A.


Clinical Trial Description

This is a research study to find out if there is a difference in the way children with hemophilia A form a clot and also evaluate if they develop tiny bleeds within the joint and subsequently early joint changes when receiving extended half-life factor VIII based replacement therapy vs non-FVIII based replacement as part of their hemophilia treatment to prevent spontaneous joint bleeds. Both therapies are standard of care therapies for patients with hemophilia A. The only experimental/research procedures as part of this study include the thrombin generation assay and ultrasound. All other procedures are standard of care. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04690322
Study type Interventional
Source University of Texas Southwestern Medical Center
Contact Jessica Garcia, MD
Phone 214-456-7000
Email Jessica.Garcia@utsouthwestern.edu
Status Recruiting
Phase Phase 4
Start date April 15, 2021
Completion date July 2025

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