Treatment of Inherited Factor VII Deficiency

Factor VII Deficiency Clinical Trial

— STER  

Official title:

Treatment of Congenital Factor VII Deficiency. A Prospective Observational Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01269138
• Other study ID #: STERProtocol7.0
• Status: Completed
• Phase: N/A
• First received: December 17, 2010
• Last updated: November 26, 2012
• Start date: January 2007
• Est. completion date: November 2012

Study information

• Verified date: November 2012
• Source: University of L'Aquila
• Contact: n/a
• Is FDA regulated: No
• Health authority: Italy: The Italian Medicines AgencyUnited States: Food and Drug Administration
• Study type: Observational

Clinical Trial Summary

FVII deficiency is a rare coagulation disorder. A limited number of patients are found in most treatment centres and countries. Treatment demands vary considerably amongst FVII deficient patients. Therefore, regular clinical studies will meet with recruitment problems in this particular patient population. The present study intends to elucidate the bleeding patterns in a well-defined collective of FVII deficiency patients who are carefully characterised, to document the actual use of different treatment modalities in different subgroups and to evaluate the efficacy and safety of current available treatment modalities in bleedings, surgery and prophylaxis. The purpose is to gain some evidence based knowledge of treatment of patients with FVII deficiency - an area where treatment decisions are made more on personal clinical experience than on consolidated clinical evidence.

This study intends to register treatment practices as they are actually performed - in a structured and documented way.

Description:

To describe the treatment modalities and outcomes of: − bleeding episodes − surgery − prophylaxis in a well defined, international cohort of FVII deficient patients characterised following the methodology used by the International Factor VII deficiency Study Group (IF7SG).

To evaluate the presence (in already treated patients) and/or the appearance of inhibiting antibodies to FVII and/or therapy-related thrombosis.

Study Design:

Prospective observational study on treatment of FVII deficiency patients. This is an outcome study conducted through the procedures set up by the IF7SG, in patients already enrolled or newly enrolled in the database.

Study population and products:

Patients with FVII deficiency (levels of FVII less than 50% of normal or a mutation known to be associated to a FVII deficiency) can be enrolled. All pharmaceutical products considered useful for treatment of FVII deficiency by the centres can be included in the study.

Key assessments:

The database is set up to capture the following assessments, if available:

Bleeding episodes:

• Recording of bleeding location, symptom onset and treatment onset & location • Recording of substitution therapy, concomitant medications and concomitant illness • Recording of 6 hour treatment evaluation for bleeding episodes • Recording of re-bleeding episodes

Surgery/delivery:

• Recording of surgery description , date of surgery and indication • Recording of substitution therapy, concomitant medications and concomitant illness during surgery • Recording of antifibrinolytic drugs used prior, during and/or after surgery •Recording of • Recording of overall treatment evaluation

Prophylaxis:

• Recording of prophylaxis type (primary/secondary), indication for prophylaxis and start/stop date •Recording of prophylaxis therapy, concomitant medications and concomitant illness • Recording of bleeding episodes during prophylaxis •Recording of clinical prophylaxis evaluation

For all:

• Laboratory values (PT/INR, APTT, FVII:C, platelet count, fibrinogen, inhibitor samples) at time points specified in section 7.3.

• Adverse events (including thrombotic events, anaphylactic reactions, DIC reactions, Re- bleedings and mortality)

• Recording of 30 day treatment evaluation (excellent, effective, partly effective, ineffective or not evaluable)

• Duration of hospital stay (ward, ICU) within 30 days after first product treatment • Mortality within 30days after first product administration

Recruitment information / eligibility

• Status: Completed
• Enrollment: 223
• Est. completion date: November 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A to 90 Years

Eligibility

Inclusion Criteria:

• Signed informed consent by the patient or next of kin or legally acceptable representative to collect data on treatment of a given bleeding episode, surgical event or prophylactic regimen as specified in the protocol.

• If informed consent is provided by the next of kin or legally acceptable representative, consent must also be obtained from the patient as soon as he/she is able to do so.Informed consent should preferentially be obtained before initiation of treatment or as a minimum before entry of data into the database. 2.Males and females 0 to 90 years of age. 3. Any patient with a FVII deficiency for whom treatment of bleeding episodes, prevention related to surgery and primary/secondary prophylaxis is considered necessary by the treating physician can be enrolled.

Exclusion Criteria:

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Factor VII Deficiency

Intervention

Drug:
• plasma derived Factor VII
Treatment of bleeding episodes,treatment during surgery and prophylaxis
• recombinant FVIIa
Treatment of bleeding episodes,treatment during surgery and prophylaxis
• Fresh Frozen Plasma
Treatment of bleeding episodes,treatment during surgery and prophylaxis
• Activated Prothrombin Complex Concentrates
Treatment of bleeding episodes,treatment during surgery and prophylaxis
• Virus Inactivated plasma
Treatment of bleeding episodes,treatment during surgery and prophylaxis

Locations

Country	Name	City	State
Italy	San Salvatore Hospital	L'Aquila	AQ

Sponsors (2)

Lead Sponsor	Collaborator
University of L'Aquila	TRIB s.r.l.

Country where clinical trial is conducted

Italy, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in Factor VII levels	To describe the treatment modalities and clinical and laboratory outcomes in: -bleeding episodes - surgery - prophylaxis in a well defined, international cohort of FVII deficient patients characterised following the methodology used by the IF7SG.	Time 0 (before treatment), 15 minutes and 1 month after treatment	Yes
Secondary	Evaluation of Inhibitor Development	To evaluate the presence (in already treated patients) and/or the appearance of inhibiting antibodies to FVII.	Monthly	Yes