Facial Palsy Clinical Trial
Official title:
Ancillary Procedures in Patients of Refractory Facial Palsy Patients Selection and Evaluation of the Outcomes
Introduction:
There are numerous causes of facial palsy (FP), though hemifacial weakness is often generally
termed Bell's palsy, named after the Scottish neurologist Charles Bell, who described sudden
onset unilateral facial paralysis in 1821.
Virally triggered, acute FP, to which the term Bell's palsy (BP) refers, is one of the most
common, and fortunately the most likely condition to result in eventual return to premorbid
status; 70% to 90% of patients recover spontaneously. Other causes of FP routinely result in
poorer recovery, and the clinician must discern among these to formulate a treatment plan.
In facial palsy, paralysis of muscles on the affected side of the face results in loss of
forehead creases, loss of the nasolabial fold, lagophthalmos, brow droop, and drooping of the
corner of the mouth. In contrast, muscles on the unaffected side of the face no longer have
opposing forces.
This may cause difficulty in articulation, eating, drinking, and is often cosmetically
unacceptable to patients because of asymmetry, especially when speaking, smiling, and
laughing. There are significant psychological effects as patients lack the confidence to
carry out many daily activities in public, such as appearing in photographs.
Although management is difficult, there are a range of reanimation options available. These
include nerve grafts, muscle transfers, myofunctional approaches, and microsurgical patches
usually for the more severe facial palsies (House-Brackmann grades 4 to 6). However, despite
these procedures, facial symmetry may not improve.
Ancillary procedures in patients of refractory facial palsy. Patients selection and
evaluation of the outcomes.
Introduction:
There are numerous causes of facial palsy (FP), though hemifacial weakness is often generally
termed Bell's palsy, named after the Scottish neurologist Charles Bell, who described sudden
onset unilateral facial paralysis in 1821.
Virally triggered, acute FP, to which the term Bell's palsy (BP) refers, is one of the most
common, and fortunately the most likely condition to result in eventual return to premorbid
status; 70% to 90% of patients recover spontaneously. Other causes of FP routinely result in
poorer recovery, and the clinician must discern among these to formulate a treatment plan.
In facial palsy, paralysis of muscles on the affected side of the face results in loss of
forehead creases, loss of the nasolabial fold, lagophthalmos, brow droop, and drooping of the
corner of the mouth. In contrast, muscles on the unaffected side of the face no longer have
opposing forces.
This may cause difficulty in articulation, eating, drinking, and is often cosmetically
unacceptable to patients because of asymmetry, especially when speaking, smiling, and
laughing. There are significant psychological effects as patients lack the confidence to
carry out many daily activities in public, such as appearing in photographs.
Although management is difficult, there are a range of reanimation options available. These
include nerve grafts, muscle transfers, myofunctional approaches, and microsurgical patches
usually for the more severe facial palsies (House-Brackmann grades 4 to 6). However, despite
these procedures, facial symmetry may not improve.
Refractory Facial Palsy:
Facial paralysis is a rare disorder, but it has significant effects on an individual, both
physical and emotional. While most patients fully recover from acute facial paralysis, a
small population is left with chronic lingering symptoms. Refractory patients are those who
had the maximum benefit of a performed procedure and need some fine touches and also those
who did not recover well of the initial condition.
Aim of the Work:
This study is aimed to evaluate the outcome of ancillary procedures in refractory cases of
facial palsy and to introduce both simple and sophisticated techniques to those patients
presented to the investigator's department.
Inclusion Criteria:
Patients with refractory Facial Palsy who did not respond well to other concerned
interferences and those who presented the maximum benefit possible of a performed procedure.
Patients & Methods:
This study will be conducted on 20 patients attendance outpatient clinic of plastic surgery
department - Assiut University Hospital.
Patients could be divided into three groups according to the anatomical site of
interferences:
- Group 1: Upper third interferences
- Group 2: Mid third interferences
- Group 3: Lower third interferences Methodology
- Botulinum toxin A (BTXA) has been used since the 1970s to treat a variety of conditions
resulting in abnormal muscle contraction or spasm. It works by preventing the release of
acetylcholine into the neuromuscular junction thereby inhibiting muscle contraction.2
Its benefits in synkinesis in facial palsy (aberrant neural regeneration of the
paralysed muscles) are well recognized.
BTXA was injected into the contralateral lower facial muscles complex to weaken the unopposed
normal muscles to improve symmetry, both active and passive.
• Gold/Platinum weight implants Implantable devices have been used to restore dynamic lid
closure in cases of severe, symptomatic lagophthalmos. These procedures are best for patients
with poor Bell phenomenon and decreased corneal sensation. Gold or platinum weights, a
weight-adjustable magnet, or palpebral springs can be inserted into the eyelids. Pretarsal
gold-weight implantation is most commonly performed.
The implants are inert and composed of 99.99% pure gold or platinum. Sizes range from 0.6-1.8
g. The weight allows the upper eyelid to close with gravity when the levator palpebrae are
relaxed. Therefore, patients must sleep with their head slightly elevated.
The implants are easily removed if nerve function returns. Complications include migration of
the implant, inflammation, allergic reaction, and extrusion.
• Tarsorrhaphy Tarsorrhaphy decreases horizontal lid opening by fusing the eyelid margins
together, increasing support of the precorneal lack of tears and improving coverage of the
eye during sleep. The procedure can be done in the office and is particularly suitable for
patients who are unable or unwilling to undergo other surgery.
Tarsorrhaphy can be performed laterally, centrally, or medially. The lateral procedure is the
most common; however, it can restrict the monocular temporal visual field.
- Brow lifting Brow ptosis is repaired with a direct brow lift. Care should be taken in
the presence of corneal decompensation because lifting the brow can cause worsening of
lagophthalmos, especially if lid closure is poor. A gold-weight implant can be placed or
lower-lid resuspension can be performed simultaneously to prevent this complication
- Suspension suture Static facial suspension procedures stabilise the muscles of mid-face
paralysis and provide facial symmetry, a better aesthetic appearance, improved chewing
and speech production in patients with facial paralysis. The new generation of
Silhouette wires for tissue suspension is a significant improvement with respect to gold
threads or Russian threads. They provide a new method of anchoring since they are made
of polypropylene with absorbable cones of polylactic acid and glycolic acid. This suture
allows tissue growth in and around the cones and therefore a strangerhood.
They were approved by the FDA in November 2006 and by the EEC in March 2007. They have been
used in over 6,000 mid-face facial aesthetic surgery interventions in the U.S. and Europe and
have recently begun to be used to treat facial paralysis.
- Fat injection Fat transfer to the face uses the patient's own adipose tissue (collected
with a minor liposuction procedure from the belly or back), which gives volume and shape
to the affected parts of the face, as well as impart glow and sheen to the skin
- Lateral Canthoplasty:
canthoplasty may be considered as one of the most valuable oculoplastic surgical procedures
to correct lid abnormalities. The indications include ectropion, entropion, lateral canthal
dystopia, horizontal lid laxity, lid margin eversion.
Evaluation of outcome:
-Subjective:- 3 Plastic surgeon will be commenting on the pre and post photography regarding
to normal side .
-Objective:- measurement between normal and effected side of the position eye brow ,Palpebral
fissure, and angle of the mouth
;
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