Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to assess the efficacy of antiviral medicine (acyclovir) in recovery of complete facial Palsy. Fifty patients (Males and females) with acute Facial Palsy within the first 3 days of onset with age ranged from 15-60 years old. Each patient was submitted to the following clinical evaluation using House and Brackmann 6 facial function scoring system and Synnybrook grading system. Neurophysiological assessment of facial nerve and muscles was done before and after the end of treatment, then after the end of first and second month of treatment. EMG was done for facial muscles of both sides beside measuring facial nerve excitability to determine the excitation threshold by recording the minimum electrical stimulus required to produce visible muscle contraction. A difference greater than 3.5 mA between the affected and unaffected side is considered significant in terms of poor prognosis. Nerve conduction study of facial nerves of both sides using concentric needle electrode. Trigeminal Blink reflex for both sides of the face. Facial functional recovery was defined as "good" or "complete" using the same criteria used in the 2001 practice guideline. An outcome of grade I or II was considered a good recovery using the House and Brackmann 6 facial function scoring system


Clinical Trial Description

The purpose of this study is to assess the efficacy of antiviral medicine (acyclovir) in recovery of complete facial Palsy. Fifty patients (Males and females) with acute Facial Palsy within the first 3 days of onset with age ranged from 15-60 years old. Each patient was submitted to the following clinical evaluation using House and Brackmann 6 facial function scoring system and Synnybrook grading system. Neurophysiological assessment of facial nerve and muscle was done before and after the end of treatment, then after the end of first and second month of treatment. EMG was done for facial muscles of both sides beside measuring facial nerve excitability to determine the excitation threshold by recording the minimum electrical stimulus required to produce visible muscle contraction. A difference greater than 3.5 mA between the affected and unaffected side is considered significant in terms of poor prognosis. Nerve conduction study of facial nerves of both sides using concentric needle electrode. Trigeminal Blink reflex for both sides of the face. Facial functional recovery was defined as "good" or "complete" using the same criteria used in the 2001 practice guideline. An outcome of grade I or II was considered a good recovery using the House and Brackmann 6 facial function scoring system ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02328079
Study type Interventional
Source Assiut University
Contact
Status Completed
Phase N/A
Start date April 2013
Completion date November 2014

See also
  Status Clinical Trial Phase
Recruiting NCT05581680 - Multimodal Quantified Analysis of Facial Movements: Comparison Between Pathological and Control Subjects N/A
Completed NCT06334796 - Artificial Intelligence-powered Virtual Assistant for Emergency Triage in Neurology Early Phase 1
Completed NCT04993417 - Comparison of Motor Imagery Technique and Mime Therapy on Facial Expressions in Facial Palsy Patients N/A
Completed NCT02486393 - Complications in Parotid Surgery N/A
Completed NCT05094245 - Stellate Gnaglion Block in Refractory Bell's Palsy N/A
Recruiting NCT04886245 - Eye-Tracking FP "A Pilot Study of the Quantitative Evaluation of the Attention Paid to Faces With Facial Palsy by the Eye-tracking Technology. N/A
Recruiting NCT03781700 - Evaluation of Cortisone Treatment in Children With Acute Facial Nerve Palsy Phase 4
Completed NCT03006783 - Assessment of the Cross-face Nerve Graft in the Treatment of Facial Paralysis N/A
Completed NCT00438087 - Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Phase 3
Recruiting NCT05981651 - Development and Application of a Dynamic Three-dimensional Quantitative Facial Measurement Device
Recruiting NCT04074018 - Impacts of Two Rehabilitation Programs on Chronic Peripheral Facial Paresis N/A
Recruiting NCT04237961 - Ancillary Procedures in Patients of Refractory Facial Palsy Patients Selection and Evaluation of the Outcomes N/A
Recruiting NCT05191719 - Neurotomy to Treat Synkinesis Following Peripheral Facial Palsy N/A
Recruiting NCT03059420 - Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies
Completed NCT03943953 - Self-guided Psychosocial Intervention for Facial Palsy N/A
Completed NCT03619720 - Emotional Perception and Production in Facial Palsy: Respiratory, Vocal and Facial Markers. N/A