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Clinical Trial Summary

Fabry disease is an inherited disorder that affects many organs in the body, including the heart. Men and women are both affected, with average life expectancy reduced by 10-20 years. The heart muscle can become thick and scarred in over half of patients, eventually resulting in heart failure, abnormal heart rhythm and death. We are focused on improving the detection of early heart disease before irreversible damage has occurred in order to improve patient outcomes. The techniques that have traditionally been used to look for disease in the heart are inadequate, as they often identify abnormalities once permanent scarring has already developed. Patients with heart damage have poor outcomes even with treatment. Therefore, it is critical to develop an earlier and reliable way to identify subtle disease in the heart, so that treatment can be initiated early when patients will benefit the most. We have previously shown that cardiac magnetic resonance imaging (MRI) can identify changes in the heart muscle in patients with Fabry disease. We hypothesize that new cardiac MRI techniques called T1 and T2 mapping will improve our ability to detect early abnormalities in the heart. Early detection of cardiac disease may enable a personalized treatment approach, potentially improving patient outcomes. The results of this study will help identify which patients might benefit from early initiation of treatment to prevent bad outcomes in the future by using cardiac MRI to identify those at higher risk.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04856059
Study type Interventional
Source University Health Network, Toronto
Contact Kate Hanneman, MD
Phone 416-323-6400
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date May 17, 2021
Completion date December 31, 2026

See also
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