Eyelid Movement Disorders Clinical Trial
Official title:
Müller's Muscle as a New Proprioceptive Organ Evidence From Immunohistochemical Staining and Electron Microscopy to Verify That the Upper Eyelid Müller's Muscle Contains Proprioceptive Innervation for Reflexive Correction of Eyelid Position
Verified date | January 2018 |
Source | Sheba Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Objectives: Upper eyelid retraction was believed to be maintained solely by voluntary
contraction of the levator palpebrae superioris (LPS) and frontalis muscles, together with
involuntary contraction of the sympathetically innervated Müller's muscle (MM). However,
several studies have suggested that the LPS also undergoes involuntary contractions, and that
a visual stimulus may not be the only trigger for frontalis muscle contractions. Recent
studies hypothesized that the MM contains proprioceptive neuronal structures, which elicit
involuntary LPS muscle contraction by the mesencephalic trigeminal nucleus via a continuous
stretch reflex. We aim to identify proprioceptive structures in MM by means of histological
examinations.
Methodology: Prospective study. Collaboration of oculoplastics, ophthalmologists and a
neuroanatomy specialist in Sheba Medical Center. 50 fresh MM specimens from patients
undergoing Müllerectomies will undergo histologic examinations, including immunohistochemical
staining and light and electron microscopy.
Significance: Identification of proprioceptive structures in MM will be the first
evidence-based proof of a proprioceptive mechanism in the eyelid. This might have a
significant impact on future surgical management of eyelid procedures. Comprehensive
understanding of the mechanisms underlying eyelid function is especially important in the
management of children with ptosis who may have coexisting amblyopia.
Status | Not yet recruiting |
Enrollment | 50 |
Est. completion date | January 15, 2021 |
Est. primary completion date | January 15, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - specimens from patients undergoing Müllerectomies Exclusion Criteria: - small specimens (<1 cm length and width) |
Country | Name | City | State |
---|---|---|---|
Israel | Sheba_Medical_Center | Ramat Gan |
Lead Sponsor | Collaborator |
---|---|
Sheba Medical Center |
Israel,
Ben Simon GJ, Blaydon SM, Schwarcz RM, Nakra T, Goldberg RA, McCann JD. Paradoxical use of frontalis muscle and the possible role of botulinum a toxin in permanent motor relearning. Ophthalmology. 2005 May;112(5):918-22. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | presence of proprioceptive organs in the muller muscle | presence of proprioceptive organs in the muller muscle | 2 years |
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