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Eye Injuries clinical trials

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NCT ID: NCT03706560 Recruiting - Occupational Stress Clinical Trials

Professional Consequences of Ocular Trauma Hospitalized at the Hospital Centre of Clermont-Ferrand

HOT-WORK
Start date: June 18, 2018
Phase:
Study type: Observational

Ocular trauma are a real public health issue. According to WHO, it is estimates at 750,000 hospital admissions per year in the world for ocular trauma, including 200,000 for open globe injuries in the world. Consequences can be severe with a significant number of definitive low vision or blindness which can lead to professionnal reclassifications for active patients. However, no study exists on professional consequences of those ocular trauma. Some studies showed that fonctionnal loss of an eye can also have psychological consequences such as post traumatic depression or can impair the quality of life but studies are scarce on this subject. The primary objective is to study the professional reclassification of workers at least 6 months after their hospitalization for ocular trauma. Secondary objectives are to assess, at least 6 months after an hospitalized ocular trauma, characteristics of eye injuries, characteristics of patients, mid-term consequences at work after eye injury and on personal aspects.

NCT ID: NCT03206723 Recruiting - Corneal Abrasion Clinical Trials

Bandage Contact Lenses for Corneal Abrasions

Start date: July 1, 2017
Phase: Phase 2
Study type: Interventional

Two percent of all patients presenting to the Emergency Departments have complaints involving the eye. Corneal abrasions are a common diagnosis with patients with eye pain and often cause significant discomfort. Current treatment includes a thorough evaluation of the eye followed by patching, empiric antibiotics, cycloplegics and oral pain medicines. This study will be a randomized controlled trial to determine the safety and efficacy of BCLs. It will involve the initial patient evaluation followed by a return visit to the Emergency Department within 36 hours for re-examination. At each visit, the patient will be assessed for the size and location of the abrasion along with their report of pain using a visual analog scale. Data will be recorded on a standard data collection sheet. Telephone contact will be made at 30 days to ensure resolution of abrasion and that no complications ensued.

NCT ID: NCT02873026 Completed - Eye Injury Trauma Clinical Trials

Adjunctive Steroid Combination in Ocular Trauma (ASCOT) Study

ASCOT
Start date: October 2014
Phase: Phase 3
Study type: Interventional

Eye trauma is a leading cause of blindness and visual impairment. Penetrating injuries of the eye are more likely to result in poor vision and the main cause of this is a scarring response on the retina (proliferative vitreoretinopathy, PVR) The purpose of this study is to investigate the potential of an anti-inflammatory treatment (triamcinolone acetonide) to improve the outcome of surgery in eyes that have suffered severe trauma.There is good evidence from laboratory studies that additional steroid treatment into and around the eye at the time of surgery could reduce scarring by reducing inflammation and improve visual outcomes.

NCT ID: NCT02638025 Completed - Eye Injuries Clinical Trials

Anterior Segment Spectral-domain Optical Coherence Tomography in Patients With Closed Globe Injury

Start date: January 2010
Phase: N/A
Study type: Observational

This study use anterior segment spectral-domain optical coherence tomography (SD-OCT) to exam patients with closed globe injury, and compared with slit lamp examination. The results showed that OCT can identify features of closed globe injury that were otherwise not visible on slit lamp biomicroscopy.

NCT ID: NCT01490593 Completed - Eye Injuries Clinical Trials

Canadian Eye Injury Registry

CEIR
Start date: March 2, 2011
Phase: N/A
Study type: Observational

The purpose of this study is to establish an eye injury registry to assess the mechanisms and outcomes of significant eye injuries occurring in Canada. The epidemiologic data will determine where public health strategies should be directed to prevent future eye injuries.

NCT ID: NCT01123044 Not yet recruiting - Eye Injury Clinical Trials

Transplantation of Cultivated Corneal Epithelial Sheet in Patients With Ocular Surface Disease

CLET
Start date: August 2011
Phase: Phase 3
Study type: Interventional

The aim of the study is to assess if transplantation of cultivated corneal epithelial stem cells could restore vision in patients with severe ocular surface disorder with a favourable safety profile that warrants further comparative study.

NCT ID: NCT00598299 Completed - Eye Injuries Clinical Trials

Comparison of the Effects on Promoting Corneal Epithelial Wound Healing Between Human Auto-Serum and Cord Blood Serum

Start date: April 2007
Phase: N/A
Study type: Observational

Human serum eye drops have been successfully used in the treatment of severe ocular surface disorders and the enhancement of corneal wound healing. Umbilical cord serum is also proven to be effective in treatment of dry eye and persistent corneal epithelial defects. However, there are limited studies comparing the corneal epithelial wound healing promoting effects between these two blood derived products. The purpose of this study is to test the corneal epithelial wound healing promoting effects between auto serum and human cord blood serum. Primary cultured bovine corneal epithelial cells were used as the model to investigate wound healing, cell proliferation and migration by means of scratch corneal wound healing assay evaluation, MTS assay and Boyden chamber migration assay in response to human serum and umbilical cord serum. The concentrations of EGF, TGF-β1, and fibronectin were also compared between human serum and umbilical cord serum with ELISA kits.

NCT ID: NCT00211367 Terminated - Eye Injuries Clinical Trials

Treatment of Radiation Retinopathy With Open-Label Anecortave Acetate Sterile Suspension (15 mg)

Start date: April 2004
Phase: Phase 2
Study type: Interventional

Radiation retinopathy is a disease of the retina. It occurs in people who have received or been exposed to radiation near the eyes. The blood vessels are abnormal and may grow which lead to scarring and a loss of central vision. Currently, the treatment for radiation retinopathy is laser photocoagulation. This treatment has been found to have limited use in this type of condition. Compassionate use of anecortave acetate injection is being considered to prevent the growth of the blood vessels under the retina.

NCT ID: NCT00129077 Completed - Critically Ill Clinical Trials

Does the Use of a Moisture Chamber Decrease the Incidence of Corneal Abrasions in Critically Ill Pediatric Patients?

Start date: March 2004
Phase: N/A
Study type: Interventional

The purpose of this study is to identify the incidence of scratches on the surface of the eye in children who cannot blink due to medication use and to identify how best to reduce the risk of a scratch on the surface of the eye when patients are using specific medicines.