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Correlation Between Exhaled Propofol Concentration With Plasma Concentration in Children

Eye Diseases Clinical Trial

Official title:
Propofol in Expiratory Air, a Comparison With Plasma Propofol, BIS Value and Calculated Plasma Concentration During General Anesthesia in Children

Clinical Trial Summary

Children due for elective eye surgery in propofol based anesthesia will be kept at steady state propofol infusion for maintenance, ventilation via endotracheal tube. Exhaled propofol will be measured continously by Edmon (R) (BBraun) monitor and compared with arterial plasma samples of propofol, drawn 3-5 times during the procedure.

Clinical Trial Description

The primary objective of the study is to determine the correlation between simultaneous concentrations of propofol in plasma and expiratory air in children during general anesthesia.

Key secondary objectives include correlating plasma and exhaled measurements of propofol with electroencephalogram (BIS) values and computer estimated propofol concentrations in plasma and brain (TCI: target control infusion) Primary endpoint: Exhaled air and plasma concentration ratios of propofol during general anesthesia in children. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04150432
Study type Interventional
Source Oslo University Hospital
Contact Johan Raeder, PhD, MD
Phone 004792249669
Email johan.rader@medisin.uio.no
Status Recruiting
Phase N/A
Start date October 30, 2019
Completion date December 31, 2021
View Details
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