Eye Abnormalities Clinical Trial
— OrganoEyeOfficial title:
Modeling Ocular Developmental Diseases From 3D Cultures of Optic Vesicle Organoids Derived From hiPSCs of Patients With Ocular Malformations
Ocular morphogenesis is a complex process starting as early as the 4th week of embryonic life, involving interactions between varioustissues of different origin and conserved genes. Anomalies in ocular development , often of genetic origin, pose diagnostic and therapeutic challenges. Animal models are limited, so human-induced pluripotent stem cell (hiPSC)-derived optic vesicle containing brain organoids (OVBOs) offer a promising alternative. These pathological OVBOs, created from patients' cells with ocular malformations, allow for the study of underlying molecular mechanisms and testing of therapies.
Status | Not yet recruiting |
Enrollment | 20 |
Est. completion date | May 2, 2034 |
Est. primary completion date | May 2, 2034 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 6 Years and older |
Eligibility | Inclusion Criteria: - Affiliated with a social security scheme. - Patients with ocular malformations. - Signed informed consent obtained from the patient and/or their legal representatives. Exclusion Criteria: - Inability to understand the nature and objectives of the study and/or difficulties in communicating with the investigator. - Deprivation of liberty by judicial or administrative decision. - Any other pathological or psychological condition deemed incompatible by the investigator for the proper conduct of the study. |
Country | Name | City | State |
---|---|---|---|
France | Purpan University Hospital | Toulouse |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Toulouse |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Culture of Optic Vesicles containing Brain Organoids (OVBOs) for the Study of Eye malformations | Macroscopic Examination and Expression of Specific Tissue Markers to Identify Optic Vesicle Anomalies | Day 60 of Development | |
Secondary | Molecular and Cellular Study of Genetically Characterized Ocular Malformations in Patients | Identification of Genetic Basis for Observed Patient Pathology | through study completion, an average of 1 year |
Status | Clinical Trial | Phase | |
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