HEMORRHOIDS Clinical Trial
Official title:
Hemorrhoids and Metalloproteinases, Observational Study
An association between hemorrhoidal disease and matrix metalloproteinases (MMPs) has been
described previously. MMPs regulate extracellular structural proteins and tissue remodeling.
Neutrophil gelatinase-associated lipocalin (NGAL) is involved in the regulation of MMP
activity. The aim of this work was to study the relationship between the levels of MMPs and
NGAL and different stages hemorrhoids.
The study provides potentially important insights to the understanding of the natural
history of Hemorrhoids and MMPs and NGAL regulation.
Introduction. An association between hemorrhoidal disease and matrix metalloproteinases
(MMPs) has been described previously. MMPs regulate extracellular structural proteins and
tissue remodeling. Neutrophil gelatinase-associated lipocalin (NGAL) is involved in the
regulation of MMP activity. The aim of this work was to study the relationship between the
levels of MMPs and NGAL and different stages hemorrhoids.
Methods. In a multicenter, open-label, prospective study, patients with hemorrhoids were
recruited and represented the Group I (patients with symptomatic hemorrhoids - Grade I to IV
sec. Goligher), a further group of healthy volunteer subjects were also recruited as the
control group (Group II).
Enzyme-linked immunosorbent assay and Western blot analysis will evaluate the levels of
immunoreactive MMPs and NGAL in all patients with hemorrhoids.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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