Effects of Collagen Peptide Supplementation on Muscle and Tendon Damage and Function

Exercise Clinical Trial

Official title:

A Randomized Double-blinded Placebo-controlled Study to Evaluate the Effect of Collagen Peptide (Collagen Peptan) Supplementation on Muscle and Tendon Damage, Repair, and Functional Capacity During Exercise Training Overload

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05425407
• Other study ID #: S64402
• Status: Completed
• Phase: N/A
• Start date: April 12, 2021
• Est. completion date: June 30, 2021

Study information

• Verified date: June 2022
• Source: KU Leuven
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the study is to investigate the acute and short-term effects of collagen peptides (Collagen Peptan) on muscle and connective tissue during an eccentric overload training period. Currently, all studies investigating the effects of post-exercise collagen supplementation did this in the absence of whey proteins, which are part of the standard recommendations for post-exercise recovery. The investigators will therefore investigate whether the combined intake of whey proteins and collagen peptides ensures a better recovery of exercise performance and whether it can prevent or reduce symptoms of muscle and tendon overload during a three-week eccentric overload training period (n = 22).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: June 30, 2021
• Est. primary completion date: May 30, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Sports participation, including general fitness training, between 2 and 5 hours max per week

• Body mass index between 18.5 and 25

Exclusion Criteria:

• Any kind of injury/pathology that is a contra-indication to perform high-intensity exercise - Intake of any medication or nutritional supplement that could impact muscle protein synthesis and/or exercise performance during the period of the study

• Intake of any whey protein, casein of branched-chain amino acid (BCAA) supplements from 1 month prior to the start of the study

• Blood donation within 3 months prior to the start of the study

• Smoking

• Current participation in another research trial

• Any other argument to believe that the subject is unlikely to successfully complete the full study

Related Conditions & MeSH terms

• Exercise
• Healthy Male Subjects

Intervention

Dietary Supplement:
• whey protein
Daily 45g of whey protein supplementation during a three week eccentric training period
• whey protein + collagen peptide
Daily 15g of whey protein and 20g collagen peptide supplementation during a three week eccentric training period

Locations

Country	Name	City	State
Belgium	Exercise Physiology Research Group	Leuven	Vlaams-Brabant

Sponsors (2)

Lead Sponsor	Collaborator
KU Leuven	Rousselot BVBA

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in countermovement jump performance	Change in jump height when performing a countermovement jump, measured via a force platform	Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)
Primary	Change in maximal isometric knee-extension force of the right leg	Change in maximal isometric knee-extension force (angle = 45°) of the right leg	Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)
Primary	Change in anteroposterior thickness of the right patellar tendon	Change in anteroposterior thickness of the right patellar tendon	Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)
Primary	Change in neovascularization of the right patellar tendon	Neovascularization of the right patellar tendon scored with the Modified Ohberg Score (range 0 - 4; the higher the score, the higher the degree of neovascularization).	Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)
Secondary	Change in pain perception at the muscular level (VAS scale)	Change in pain perception at the muscular level of the right leg, measured via the Visual Analogue Scale (range 0 - 10; the higher the score, the higher the pain level)	Training 1 (day 1 of training intervention) - Training 2 (day 3 of training intervention) - Training 8 (day 9 of training intervention) - Training 17 (day 19 of training intervention) - Posttest (day 22 of training intervention)
Secondary	Change in pain perception of the patellar tendon of the right leg (VISA-P)	Change in pain perception of the patellar tendon of the right leg, measured via the VISA-P questionnaire (range: 0 - 100; the lower the score, the higher the symptoms of patellar tendon overload)	Pretest - Training 1 (day 1 of training intervention) - Training 17 (day 21 of training intervention) - Posttest (day 22 of training intervention)
Secondary	Change in the blood concentration of creatine kinase	Change in blood concentration of creatine kinase (marker of muscle damage)	Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)
Secondary	Change in the blood concentration of Interleukin 6 (IL-6)	Change in blood concentration of Interleukin 6 (IL-6; marker of inflammation)	Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)
Secondary	Change in the blood concentration of N-terminal propeptide of type I procollagen (P1NP)	Change in blood concentration of N-terminal propeptide of type I procollagen (P1NP; marker of collagen synthesis)	Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)