Muscle Typology and Strength Training Adaptations

Exercise Clinical Trial

— MT-ST  

Official title:

Influence of Muscle Typology and Training Frequency on Chronic Strength Training Adaptations

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05108181
• Other study ID #: BC-10253
• Status: Completed
• Phase: N/A
• Start date: September 9, 2021
• Est. completion date: December 8, 2023

Study information

• Verified date: April 2024
• Source: University Ghent
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers. Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: December 8, 2023
• Est. primary completion date: December 8, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Fast or slow muscle typology
• 18 - 45 years old
• no strength training experience

Exclusion Criteria:

• Vegan/vegeterian diet
• Supplement intake
• chronic diseases
• Hypertension,
• Smoking
• Medication use
• Coagulation disorder, infectious diseases

Related Conditions & MeSH terms

• Exercise

Intervention

Other:
• Muscle typology + exercise training
Exercise training: Participants perform 9 weeks of strength training at 60% of their 1RM.
• Muscle typology + training frequency
Training frequency: leg A and arm A of the participants train 3 times per week, leg B and arm B train 2 times per week.

Locations

Country	Name	City	State
Belgium	Department of Movement and Sports Sciences, Ghent University	Gent	Oost-Vlaanderen

Sponsors (1)

Lead Sponsor	Collaborator
University Ghent

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change from baseline muscle volume at 9 weeks	Muscle volume of the legs and the upper arms - MRI	Pre and post the 9 weeks training period
Primary	Change from baseline dynamic muscle strength at 3 weeks	Upper legs and upper arms - strength training devices	Pre, mid and post 9 weeks training period
Primary	Change from baseline dynamic muscle strength at 6 weeks	Upper legs and upper arms - strength training devices	Pre, mid and post 9 weeks training period
Primary	Change from baseline dynamic muscle strength at 9 weeks	Upper legs and upper arms - strength training devices	Pre, mid and post 9 weeks training period
Primary	Change from baseline isometric muscle strength at 9 weeks	Upper legs and upper arms - Biodex	Pre and post 9 weeks training period
Primary	Change in muscle fiber type specific hypertrophy at 9 weeks	Legs - Biopsy (vastus lateralis)	Pre and post 9 weeks training period
Secondary	Change of baseline antropometry at 9 weeks	Height, weight, skinfolds	Pre and post 9 weeks training period
Secondary	Change of baseline skeletal muscle protein content at 9 weeks	Histochemistry and protein content of markers of relevance for skeletal muscle function	Pre and post 9 weeks training period
Secondary	Change of baseline histochemistry at 9 weeks	Histochemistry of markers of relevance for skeletal muscle function	Pre and post 9 weeks training period
Secondary	Change from basline fatigue feeling over 9 weeks training period	Number of repetitions during every training, questionnaire (VAS-scale) before every training, RPE after every training	Assessed every training during the 9 weeks training period
Secondary	Change from baseline fasting insulin, glucose, cholesterol and triglycerides at 9 weeks	Fasted blood samples	Pre and post 9 weeks training period