Exercise Clinical Trial
— PECSOfficial title:
The Effects of Essential and Non-Essential Amino Acids on Post-Exercise Muscle Collagen Synthesis in Young Men: a Randomized Controlled Trial
Verified date | June 2023 |
Source | University of British Columbia |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to assess which amino acids are affecting acute muscle collagen synthesis in response to supplementation and exercise.
Status | Completed |
Enrollment | 17 |
Est. completion date | February 13, 2022 |
Est. primary completion date | February 13, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: - Can fluently read and write in English - Male - 18 - 35 years Exclusion Criteria: - Diabetes, cardiovascular disease, or current pharmaceutical therapy - Medical conditions impacting ability to undertake strenuous physical activity - Lower body resistance training in the previous 6 months - BMI > 30 - Currently smoking with cigarettes - Allergy to any study supplements - Currently taking any protein, amino acid, or collagen supplement - Participate in greater than 2 hours of weekly vigorous exercise |
Country | Name | City | State |
---|---|---|---|
Canada | Chan Gunn Pavilion | Vancouver | British Columbia |
Lead Sponsor | Collaborator |
---|---|
University of British Columbia |
Canada,
Alcock RD, Shaw GC, Tee N, Burke LM. Plasma Amino Acid Concentrations After the Ingestion of Dairy and Collagen Proteins, in Healthy Active Males. Front Nutr. 2019 Oct 15;6:163. doi: 10.3389/fnut.2019.00163. eCollection 2019. — View Citation
Egerman MA, Glass DJ. Signaling pathways controlling skeletal muscle mass. Crit Rev Biochem Mol Biol. 2014 Jan-Feb;49(1):59-68. doi: 10.3109/10409238.2013.857291. Epub 2013 Nov 18. — View Citation
Frontera WR, Ochala J. Skeletal muscle: a brief review of structure and function. Calcif Tissue Int. 2015 Mar;96(3):183-95. doi: 10.1007/s00223-014-9915-y. Epub 2014 Oct 8. — View Citation
Holm L, Rahbek SK, Farup J, Vendelbo MH, Vissing K. Contraction mode and whey protein intake affect the synthesis rate of intramuscular connective tissue. Muscle Nerve. 2017 Jan;55(1):128-130. doi: 10.1002/mus.25398. Epub 2016 Sep 26. — View Citation
Holm L, van Hall G, Rose AJ, Miller BF, Doessing S, Richter EA, Kjaer M. Contraction intensity and feeding affect collagen and myofibrillar protein synthesis rates differently in human skeletal muscle. Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E257-69. doi: 10.1152/ajpendo.00609.2009. Epub 2009 Nov 10. — View Citation
Miller BF, Olesen JL, Hansen M, Dossing S, Crameri RM, Welling RJ, Langberg H, Flyvbjerg A, Kjaer M, Babraj JA, Smith K, Rennie MJ. Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise. J Physiol. 2005 Sep 15;567(Pt 3):1021-33. doi: 10.1113/jphysiol.2005.093690. Epub 2005 Jul 7. — View Citation
Shaw G, Lee-Barthel A, Ross ML, Wang B, Baar K. Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis. Am J Clin Nutr. 2017 Jan;105(1):136-143. doi: 10.3945/ajcn.116.138594. Epub 2016 Nov 16. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Fractional synthetic rate (change over time) of Myofibrillar Protein Synthesis | Fraction of the myofibrillar enriched protein from muscle biopsy per unit time. | 0 - 4 hours post-exercise | |
Primary | Fractional synthetic rate (change over time) of Myofibrillar Protein Synthesis | Fraction of the myofibrillar enriched protein from muscle biopsy per unit time. | 0 - 2 hours post-exercise | |
Primary | Fractional synthetic rate (change over time) of Myofibrillar Protein Synthesis | Fraction of the myofibrillar enriched protein from muscle biopsy per unit time. | 2 - 4 hours post-exercise | |
Primary | Fractional synthetic rate (change over time) Muscle Collagen Synthesis | Fraction of the intramuscular collagen enriched protein from muscle biopsy per unit time. | 0 - 4 hours post-exercise | |
Primary | Fractional synthetic rate (change over time) Muscle Collagen Synthesis | Fraction of the intramuscular collagen enriched protein from muscle biopsy per unit time. | 0 - 2 hours post-exercise | |
Primary | Fractional synthetic rate (change over time) Muscle Collagen Synthesis | Fraction of the intramuscular collagen enriched protein from muscle biopsy per unit time. | 2 - 4 hours post-exercise | |
Primary | Pro-Collagen Type I N-Propeptide (PINP) | Osteoblastic marker of bone collagen synthesis | 1 hour prior to exercise | |
Primary | Pro-Collagen Type I N-Propeptide (PINP) | Osteoblastic marker of bone collagen synthesis | 4 hours post exercise | |
Secondary | Plasma Amino Acids Response to Supplementation | Amino acid plasma concentrations | 0 - 4 hours post-exercise | |
Secondary | Muscle mechanistic target of rapamycin Pathway Activation | Measuring the fold change in enzymes associated with the anabolic signalling of the mTOR pathway (e.g. phosphoinositide 3-kinases (PI3k), protein kinase B (Akt)) | 0 - 4 hours post-exercise | |
Secondary | PCR Gene Expression of Muscle Collagen Genes (Types I, III, IV) | Measuring the fold change when the collagen genes of interest become detectable in the PCR analysis | 0 - 4 hours post-exercise | |
Secondary | Pro-Collagen Type III N-Propeptide (PIIINP) | Marker of collagen synthesis | 1 hour prior to exercise | |
Secondary | Pro-Collagen Type III N-Propeptide (PIIINP) | Marker of collagen synthesis | 4 hours post exercise |
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