Carbohydrate Feeding Frequency, Muscle Glycogen and Exercise Capacity in Runners

Exercise Clinical Trial

Official title:

The Effect of Carbohydrate Feeding Frequency on Muscle Glycogen and Exercise Capacity in Runners

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03749785
• Other study ID #: 18/SW/0177
• Status: Completed
• Phase: N/A
• Start date: October 14, 2018
• Est. completion date: April 16, 2019

Study information

• Verified date: March 2019
• Source: University of Bath
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to investigate the effects of regular sucrose feeds compared to a single large bolus given late in exercise, on muscle glycogen utilisation, exercise capacity and other markers of metabolism during running

Recruitment information / eligibility

• Status: Completed
• Enrollment: 7
• Est. completion date: April 16, 2019
• Est. primary completion date: March 20, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Self-identify as a trained runner

• Regularly participate in running activity (>2 times a week)

• Participated in running based training for a minimum of 2 years

• Be willing to undertake exercise sessions until volitional exhaustion

• Be willing to have the necessary samples taken during the testing protocols

• Not a habitual smoker

• Have the capacity and willingness to provide informed consent (oral and written)

• Successful completion of the physical activity readiness questionnaire (PAR-Q)

Exclusion Criteria:

• Female

• <18 or >50 years old

• Not regularly participating in running activity (<3 times a week)

• Experience contraindications to the administration of the proposed anaesthetic (Lidocaine Hydrochloride)

• Habitual/previously habitual smoker

Related Conditions & MeSH terms

• Exercise

Intervention

Other:
• Regular carbohydrate feeding
60 ml of water with 5 g sucrose given every 5 minutes 14 times up until 70 minutes followed by 5 g sucrose after 75 minutes in a 250 ml solution
• Single carbohydrate bolus
60 ml of water given every 5 minutes 14 times up until 70 minutes followed by 75 g sucrose after 75 minutes in a 250 ml solution

Locations

Country	Name	City	State
United Kingdom	Department for Health, University of Bath	Bath

Sponsors (1)

Lead Sponsor	Collaborator
University of Bath

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle glycogen concentrations	Muscle glycogen concentration at rest, after 75 minutes of treadmill running and at volitional exhaustion. Measured using the bergstrom needle technique for obtaining muscle biopsy samples	Estimated to be between 90 and 145 minutes
Primary	Exercise capacity	Time to exhaustion at the pre-determined speed to elicit exhaustion after ~90 minutes when ingesting water only	Estimated to be between 90 and 145 minutes
Secondary	Ratings of perceived exertion	Subjective ratings of perceived exertion, during treadmill running. Measured using a borg scale of 6 to 20, where 6 = no exertion at all, and 20 = maximal exertion.	Estimated to be between 90 and 145 minutes
Secondary	Ratings of stomach discomfort	Subjective ratings of stomach discomfort during treadmill running. Measured using a modified borg scale of 6 to 20, where 6 = no discomfort and 20 = maximal discomfort	Estimated to be between 90 and 145 minutes
Secondary	Carbohydrate oxidation	Total carbohydrate oxidation during treadmill running. Measured using indirect calorimetry and reported in grams.	Estimated to be between 90 and 145 minutes
Secondary	Fat oxidation	Total fat oxidation during treadmill running. Measured using indirect calorimetry and reported in grams.	Estimated to be between 90 and 145 minutes
Secondary	Plasma glucose concentrations	Plasma lactate concentrations during of treadmill running. Measured using colourimetric assay and reported in mmol/L	Estimated to be between 90 and 145 minutes
Secondary	Plasma lactate concentrations	Plasma lactate concentrations during treadmill running. Measured using colourimetric assay and reported in mmol/L.	Estimated to be between 90 and 145 minutes
Secondary	Heart rate	Heart rate during treadmill running measured by telemetry and reported in beats per minute	Estimated to be between 90 and 145 minutes
Secondary	Rate of oxygen consumption	Rate of oxygen consumption during treadmill running. Measured using indirect calorimetry and reported in litres per minute	Estimated to be between 90 and 145 minutes
Secondary	Rate of carbon dioxide production	Rate of carbon dioxide production during treadmill running. Measured using indirect calorimetry and reported in litres per minute.	Estimated to be between 90 and 145 minutes