Exogenous Oxidation of Fructose-glucose Mixtures During Running

Exercise Clinical Trial

Official title:

Examining Exogenous Carbohydrate Oxidation From Glucose, Multiple Transportable Carbohydrates and Hydrogel Carbohydrate Drinks During Endurance Running

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03731065
• Other study ID #: MSES 17/18-001
• Status: Completed
• Phase: N/A
• Start date: October 14, 2018
• Est. completion date: November 30, 2019

Study information

• Verified date: December 2019
• Source: University of Bath
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to characterise exogenous carbohydrate oxidation rates during exercise, when ingesting glucose (polymers) only, compared to glucose-fructose mixtures, and glucose-fructose mixtures ingested in hydrogel form.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 9
• Est. completion date: November 30, 2019
• Est. primary completion date: October 30, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Maximal oxygen consumption > 50 ml.kg-1.min-1

• > 1 year training in endurance running or triathlon

• No current injury or injury within the last three months

• No history of cardiac or metabolic disease such as coronary heart disease or diabetes

• No current or history of gastrointestinal issues

• Successful completion of the physical activity readiness questionnaire (PAR-Q)

Exclusion Criteria:

• Female

• Untrained in endurance running

• Current injury or injury within the past three months

• History of cardiac or metabolic disease such as coronary heart disease or diabetes

• History of or current gastrointestinal issues such as irritable bowel syndrome

• Unable to replicate diet and training for 3 and 5 days respectively prior to each experimental visit.

Related Conditions & MeSH terms

• Exercise

Intervention

Dietary Supplement:
• Fructose-maltodextrin
Fructose plus maltodextrin in a ratio of 1:1.4, diluted in water to produce a 16% carbohydrate solution.
• Fructose-maltodextrin hydrogel
Fructose plus maltodextrin in a ratio of 1:1.4, encapsulated in an alginate-pectin hydrogel diluted in water to produce a 16% carbohydrate solution.
• Glucose-maltodextrin
Glucose plus maltodextrin in a ratio of 1:1.4, diluted in water to produce a 16% carbohydrate solution.

Locations

Country	Name	City	State
United Kingdom	Department for Health, University of Bath	Bath

Sponsors (2)

Lead Sponsor	Collaborator
University of Bath	University of Birmingham

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Peak exogenous carbohydrate oxidation rate	Peak exogenous carbohydrate oxidation rate during 120 min of treadmill running. Measured using isotope ratio mass spectrometry and reported in grams per minute	120 minutes
Secondary	Total carbohydrate oxidation	Total carbohydrate oxidation during 120 min of treadmill running. Measured using indirect calorimetry and reported in grams.	120 minutes
Secondary	Ratings of gastrointestinal discomfort	Subjective ratings of gastrointestinal discomfort during 120 min of treadmill running. Measured using a 9-item questionnaire on a scale of 1 to 7, where 1 = No discomfort at all and 7 = very severe discomfort.; Items: Stomach; Heartburn; Acid reflux; Nausea; Rumbling; Bloated; Burping; Passing gas; Bowel movement.	120 minutes
Secondary	Total fat oxidation	Total fat oxidation during 120 min of treadmill running. Measured using indirect calorimetry and reported in grams.	120 minutes
Secondary	Plasma insulin concentrations	Plasma insulin concentrations during 120 min of treadmill running. Measured using enzyme-linked immunosorbent assay and reported in pmol/L.	120 minutes
Secondary	Plasma glucose concentrations	Plasma lactate concentrations during 120 min of treadmill running. Measured using colourimetric assay and reported in mmol/L.	120 minutes
Secondary	Plasma lactate concentrations	Plasma lactate concentrations during 120 min of treadmill running. Measured using colourimetric assay and reported in mmol/L.	120 minutes
Secondary	Plasma non-esterified fatty acid concentrations	Plasma insulin concentrations during 120 min of treadmill running. Measured using colourimetric assay and reported in umol/L.	120 minutes
Secondary	Ratings of perceived exertion	Subjective ratings of perceived exertion using the Borg scale (1982) during 120 min of treadmill running. Measured on a scale of 6 to 20, where 6 = no exertion at all, and 20 = maximal exertion.	120 minutes
Secondary	Heart rate	Heart rate during treadmill running measured by telemetry and reported in beats per minute.	120 minutes
Secondary	Rate of oxygen consumption	Rate of oxygen consumption during 120 min of treadmill running. Measured using indirect calorimetry and reported in litres per minute.	120 minutes
Secondary	Rate of carbon dioxide production	Rate of carbon dioxide production during 120 min of treadmill running. Measured using indirect calorimetry and reported in litres per minute.	120 minutes