Exercise Clinical Trial
Official title:
Whey Protein Support to Metabolic and Performance Adaptations in Response to High Intensity Interval Training in Young Adult Men
Verified date | January 2020 |
Source | University of Limerick |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
High intensity interval training (HIIT) has recently emerged as a time efficient alternative
to conventional endurance exercise, conferring similar or superior benefits in terms of
metabolic and performance adaptations in both athletic and non-athletic populations. Some of
these physiological adaptations include augmented mitochondrial biogenesis and improved
substrate metabolism in peripheral tissues such as skeletal muscle. However, nutritional
strategies to optimise the adaptations to HIIT have yet to be established. Recent evidence
suggests that acute nutritional status can affect the molecular regulation of genes mediating
substrate metabolism and mitochondrial biogenesis. Moreover, preliminary evidence suggests
that completion of exercise in fasted conditions augments some of these exercise-induced
adaptations compared with the fed state. Given the fact that the transient molecular
adaptations to acute exercise mediate long-term physiological adaptations, an investigation
into the effects of different nutritional interventions on metabolic and performance
responses to HIIT is warranted.
The purpose of this study is to determine the effects of fasted vs. fed-state (Whey Protein)
HIIT on metabolic and performance adaptations in the acute (single exercise session) and
chronic (3 weeks, 9 exercise sessions) phases. The primary hypothesis is that different
pre-exercise feeding conditions (e.g. fasted placebo vs. Whey protein fed) will result in
divergent physiological adaptations in terms of skeletal muscle metabolism and performance,
both in response to a single HIIT session and a chronic HIIT intervention.
Status | Completed |
Enrollment | 35 |
Est. completion date | February 1, 2019 |
Est. primary completion date | February 1, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - Healthy (absence of clinical condition) - Recreationally active - Aerobically untrained (VO2max <50 ml.kg.min-1) - Protein sufficient (>0.8 g.kg.d-1) - Males - Able to provide informed consent - No contraindications to high intensity exercise Exclusion Criteria: - BMI >30 kg.m-2 - Metabolic disease (mitochondrial, Type 2 Diabetes) |
Country | Name | City | State |
---|---|---|---|
Ireland | University of Limerick | Limerick | Munster |
Lead Sponsor | Collaborator |
---|---|
University of Limerick |
Ireland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Organelle Biogenesis (Mitochondrial) Acute | Acute phase - change in Peroxisome Proliferator Activated Receptor 1 alpha (PGC-1a) messenger ribonucleic acid (mRNA) expression in response to a single HIIT session. Measured using real-time polymerase chain reaction (RT-PCR). | Acute - 3 hours post exercise session 1 | |
Primary | Exercise Performance | Mean power output (Watts) during 20 minute cycling performance test. Measured using cycle ergometer and associated software. | Chronic - 72 hours post exercise session 9 | |
Primary | Anaerobic Exercise Performance | Anaerobic exercise performance peak power (Watts). Measured using 30 second Wingate test on a Monark 894E cycle ergometer. | Chronic - 72 hours post exercise session 9 | |
Primary | Organelle Biogenesis (Mitochondrial) Chronic | Chronic Phase - change in Citrate Synthase Activity measured using commercially available assay kits. | Chronic - 48 hours post exercise session 9 | |
Secondary | Organelle Biogenesis (Mitochondrial) | Pyruvate Dehydrogenase Kinase 4 (PDK4), Peroxisome Proliferator Activated Receptor (PPAR) delta, Sirtuin 1 (SIRT1) mRNA expression. Measured using real-time polymerase chain reaction (RT-PCR). | Acute: 3 hours post HIIT session 1. | |
Secondary | Cycling Economy | Cycling economy (W.VO2 L.min-1) during multiple incremental stages (50 W, 100 W, 150 W, 200 W, 250 W) of a submaximal cycling test. | Chronic - 72 hours post exercise session 9 |
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