Myocellular Signalling in Skeletal Muscle

Exercise Clinical Trial

Official title:

Insulin-dependent and Exercise-induced Myocellular Signalling in Skeletal Muscle

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03203317
• Other study ID #: TIN-X
• Status: Completed
• Phase: N/A
• First received: April 26, 2017
• Last updated: July 29, 2017
• Start date: May 1, 2017
• Est. completion date: July 26, 2017

Study information

• Verified date: July 2017
• Source: University of Copenhagen
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study will investigate myocellular signalling in skeletal muscle after insulin-stimulation and exercise in healthy young men

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: July 26, 2017
• Est. primary completion date: July 26, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• healthy

• informed consent

• habitual training (2-5 h/week)

• VO2max of 40-60 ml/min/kg

• lean mass 55-65 kg

Exclusion Criteria:

• smoker

• allergy towards insulin

• chronic disease

Related Conditions & MeSH terms

• Exercise
• Insulin Resistance
• Insulin Sensitivity

Intervention

Drug:
• Insulin
2 h insulin clamp

Other:
• Exercise
Cycling exercise

Locations

Country	Name	City	State
Denmark	August Krogh Building	Copenahgen

Sponsors (1)

Lead Sponsor	Collaborator
University of Copenhagen

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in muscle phospho-proteome signature	proteomic analysis of mixed muscle homogenate	Before and after 10 minutes of exercise, as well as before and after a 2 hour insulin stimulation