The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults

Exercise Clinical Trial

Official title:

The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02825823
• Other study ID #: H1601260
• Status: Completed
• Phase: N/A
• First received: July 4, 2016
• Last updated: October 12, 2017
• Start date: July 2016
• Est. completion date: June 1, 2017

Study information

• Verified date: October 2017
• Source: University of British Columbia
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone salt, is proposed to have ergogenic potential for high-intensity exercise performance but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone salts can alter fuel use during exercise and improve exercise performance.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: June 1, 2017
• Est. primary completion date: June 1, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Males aged 18-40

• Ability to understand and communicate in English to answer questionnaires and interact with the research assistant

• Physically active (defined by engaging in moderate-to-vigorous exercise at least 3 times per week, determined via validated questionnaire)

Exclusion Criteria:

• Diagnosed with diabetes or any other medical conditions that could affect metabolism.

• Diagnosed with heart disease or taking anti-hypertensive medications.

• Competitive endurance athlete (self-identified as engaged in specific endurance training in triathlon, cycling, or distance running and competing in races or competition)

• Recent (last 3 months) or current consumption of a low-carbohydrate ketogenic diet

• Current consumption of ketone supplements

• Any other contraindication to vigorous exercise (identified via physical activity readiness questionnaire [PAR-Q])

Related Conditions & MeSH terms

• Dietary Supplements
• Exercise
• Ketones

Intervention

Dietary Supplement:
• Ketone Salt

• Placebo

Locations

Country	Name	City	State
Canada	University of British Columbia, Okanagan.	Kelowna	British Columbia

Sponsors (1)

Lead Sponsor	Collaborator
University of British Columbia

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Respiratory Exchange Ratio (RER) during cycling exercise	The RER during 18 minutes of steady-state exercise	0-18 minutes
Secondary	10 km Cycling Time Trial Performance	10 km time trial performed on a stationary bicycle following 18 minutes of steady-state exercise	Following 18 minutes of steady-state exercise