The Effects of Acute Caloric Deprivation on Odour Identification and Food Reward

Exercise Clinical Trial

— DEXDER  

Official title:

The Effects of Acute Caloric Deprivation on Odour Identification and Food Reward

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02653378
• Other study ID #: H09-09-03
• Status: Completed
• Phase: N/A
• First received: January 6, 2016
• Last updated: January 8, 2016
• Start date: November 2009
• Est. completion date: March 2012

Study information

• Verified date: January 2016
• Source: University of Ottawa
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Ethics Review Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine how the modality of energy depletion can differently impact appetite hormones, ad libitum food intake, food hedonics, and olfaction.

Description:

The objectives of the current randomized controlled study were to examine how the modality of an acute 3 day isocaloric -25% energy depletion by dieting alone or by aerobic exercise alone differently impacts appetite and appetite-related hormones, ad libitum energy intake (EI), food hedonics and food reward, and olfaction. It was hypothesized that independent of modality of depletion, that relative to the control, there would be increased ad libitum feeding and food reward, improvements in smell performance, and a decline in fasting leptin and increase in fasting total ghrelin. It was also hypothesized that the increased food reward would prove to be a predictor of ad libitum EI and that relative to the depletion by aerobic exercise alone, the depletion by diet alone would produce greater compensatory increases in appetite, ad libitum EI, and food reward.

Statistics

To test for differences in body weight, plasma hormone concentrations, relative-reinforcing value of food (RRVF), and olfaction across each condition of the study, repeated measures ANOVA controlling for day 1 as a covariate was employed. Pairwise comparisons at day 4 using Sidak adjustment to account for multiple comparisons are reported when the ANOVA was significant. One way repeated measures ANOVAs with Sidak adjustments for multiple comparisons were used to test for differences in variables measured only at day 4: body composition (fat mas, %Fat, and fat free mass), appetite, palatability, and ad libitum EI.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: March 2012
• Est. primary completion date: March 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Free from any illness that could influence outcome of the experiment

• Weight-stable for >6months

• aged between 18-40 years

Exclusion Criteria:

• diabetic

• smoker

• medication

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Diet
• Energy Depletion
• Exercise
• Food Hedonics
• Food Reward
• Olfaction

Intervention

Behavioral:
• DIET
25% Energy Depletion by Diet only for 3 Days
• EX
25% Energy Depletion by Exercise only for 3 Days

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Ottawa

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Ad Libitum Energy Intake at Buffet Lunch--total kcals consumed at lunch meal measured to nearest 0.5grams.	Ad libitum measure of energy intake at lunch time at Day 1 and Day 4 of study	Day 1 and Day 4 of each study arm (DIET and EX)	No
Secondary	Change in fasting measure of Leptin	One fasting sample of plasma Leptin	Day 1 and Day 4 of each study arm (DIET and EX)	No
Secondary	Change in fasting measure of Ghrelin	One fasting sample of plasma Ghrelin taken at Day 1 and Day 4 of study	Day 1 and Day 4 of each study arm (DIET and EX)	No
Secondary	Change in Relative-Reinforcing Value of Food as measured by food points earned during a computerized behavioral choice tast	Computer task measuring reinforcing value of preferred snack food and preferred fruit at Day 1 and Day 4 of study	Day 1 and Day 4 of each study arm (DIET and EX)	No
Secondary	Olfaction--Odor Detection Threshold measured by Sniffin Sticks odorized pens	Measure of odour threshold for n-butanol taken at Day 1 and Day 4 of study	Day 1 and Day 4 of each study arm (DIET and EX)	No