Exercise Clinical Trial
— HITCaOfficial title:
Effectiveness of Short Term, High Intensity, Interval Exercise Training in Older Colorectal Cancer Patients in Improving Preoperative Fitness
Verified date | July 2017 |
Source | University of Nottingham |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The primary aim of this study is to determine whether an improvement in aerobic fitness, as judged by an increase in VO2peak, can be achieved within 31 days via HIT programme in a group of older, colorectal cancer patients.
Status | Completed |
Enrollment | 18 |
Est. completion date | April 2017 |
Est. primary completion date | April 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 88 Years |
Eligibility |
Inclusion Criteria: - Confirmed colorectal cancer - Offered curative treatment by the Royal Derby Hospital NHS Foundation Trust Colorectal Cancer Multidisciplinary Team - Male and female - 18-88 years of age Exclusion Criteria: - Uncontrolled hypertension (BP > 160/100), - Angina, - Heart failure (class III/IV), - Cardiac arrthymias, - Right to left cardiac shunt, - Recent cardiac event, - Previous stroke/TIA, - Aneurysm (large vessel or intracranial), - Severe respiratory disease including pulmonary hypertension, - COPD/asthma with an FEV1 less than 1.5 l, - Coagulation disorders, - Scarring disorders. - Current neoadjuvant chemo/radiotherapy - Inability to complete the consent process Involvement in invasive research study in previous 3 months. |
Country | Name | City | State |
---|---|---|---|
United Kingdom | University of Nottingham | Derby | Derbyshire |
Lead Sponsor | Collaborator |
---|---|
University of Nottingham | Derby Hospitals NHS Foundation Trust |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | VO2 peak | Mean difference in VO2 peak following a HIT programme | After 31 days of HIT | |
Secondary | Anaerobic threshold | Mean difference in anaerobic threshold following a HIT programme | After 31 days of HIT | |
Secondary | Muscle protein synthesis | Assessment of D2O evaluated muscle protein synthesis following HIT programme | After 31 days of HIT | |
Secondary | Body composition | DXA and USS assessed changes in lean muscle mass and architecture following a HIT programme | After 31 days of HIT | |
Secondary | Feasibility | Determination of patient compliance and adherence to HIT programme | After 31 days of HIT | |
Secondary | Quality of life | Quality of life and performance questionnaires to measure subjective outcomes (EQ-5D, IPAQ, DASI, WEMWBS) | After 31 days of HIT |
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