Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT04641117 |
| Other study ID # |
UTexasAustinKHE |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
January 1, 2021 |
| Est. completion date |
December 31, 2026 |
Study information
| Verified date |
November 2020 |
| Source |
University of Texas at Austin |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
Participants will be 60-80 y men and women who vary their physical activity (steps/day) while
their lipid metabolism is studied (n=24). Thereafter, another group (n=60) will perform 6
months of exercise training focused on developing maximal cycling power, during which their
changes in muscle mass and practical function will be carefully measured.
Description:
In a society that is growing in the number of older adults who are also becoming more
sedentary, it is critical to identify the types of exercise that harness significant health
benefits. First, we hypothesize that older adults (60-80 y) need a certain background level
of physical activity, judged by number of steps per day. This is important, especially to fat
metabolism. Secondly, because older adults claim they don't have time to exercise, we have
developed a time efficient program (10 min/day) that has shown promise for offsetting
sarcopenia and significantly improving cardiovascular function.
Our Aim 1 is to determine the range of daily step counts in older adults (60-80 y; n=24) that
is needed to prevent acute impairment of post-prandial fat metabolism, measured the morning
after exercise. We have recently shown in young adults that when their level of background
physical activity drops below the range of 5,000 - 8,500±500 steps/d, that they don't adapt
positively to an acute 1 h bout of exercise (i.e.; 'exercise resistance') that normally
improves fat metabolism.
Our Aim 2 is to determine the ability of a time-efficient 24-week program of exercise
training for both maximal neuromuscular power and aerobic power to counteract sarcopenia and
declines in aerobic power and functional tests in men and women 60-80 y. We have recently
found in a preliminary study of older men and women (50-70 y) that performing multiple
maximal 4 s sprints of rapid acceleration cycling bouts for only 8 weeks, eliciting maximal
power, displayed significant (p<0.05) increases in muscle thigh volume (MRI), whole body
muscle mass, maximal neuromuscular power and peak oxygen consumption. We now propose to train
older men and women (i.e.; 60-80 y; n=60) for longer durations (i.e.; 24 weeks) and describe
the time course of adaptations. We will additionally monitor their background levels of daily
physical activity and determine if it correlates with improvements in neuromuscular and
cardiovascular function.
